Aiswarya Lekshmy, S U (2013) Study of Interleukin 8 and Interleukin 1B in Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders. Masters thesis, Ragas Dental College and Hospital, Chennai.
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Abstract
BACKGROUND: Oral cancer is a fatal disease with a bad prognosis. It is often preceded by oral potentially malignant disorders (OPMD). Cytokines Interleukin-8 (IL8) and Interleukin-1Beta (IL1B) are produced in a dysregulated fashion in oral cancer. Salivary levels of these cytokines may be early markers of malignant transformation of OPMD. AIM AND OBJECTIVE: To study the levels of Interleukin-8 and Interleukin1B in saliva of patients with oral squamous cell carcinoma (OSCC), oral potentially malignant disorders and normal controls. MATERIALS AND METHODS: Saliva from 18 subjects with OSCC, 16 subjects with Oral submucous fibrosis (OSF), 14 subjects with Leukoplakia (Dysplasia) and 24 normal patients constituted the study group. Salivary IL 8 and IL1B were analysed using solid phase sandwich Enzyme Linked Immunosorbant Assay (ELISA) technique. RESULTS: Levels of salivary IL 8 and IL1B were significantly elevated in OSCC when compared to controls. OPMD showed no significant difference when compared to controls. CONCLUSION: Salivary levels of IL 8 and IL 1B are higher in OSCC than in OPMD and normal. The levels in OPMD and normal were similar. Based on our results, in a limited sample, the cytokine IL 8 is useful in identifying transformation of OPMD. IL 1B shows potential in leukoplakia.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Saliva ; Biomarker ; Cytokines ; Interleukin 8 ; Interleukin IB ; Oral squamous cell carcinoma. |
| Subjects: | DENTAL > Oral Pathology and Microbiology |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Nov 2017 13:29 |
| Last Modified: | 12 Nov 2017 13:29 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3904 |
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