Cell Proliferation in Oral Squamous Cell Carcinoma in Different Subsites.

Arya, A N (2013) Cell Proliferation in Oral Squamous Cell Carcinoma in Different Subsites. Masters thesis, TamilNadu Government Dental College and Hospital, Chennai.


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BACKGROUND: Cell proliferation rate is one of the important determinants of prognosis in cancer. Oral cancer prognosis differs among different subsites and it is also influenced by the etiological factors. AIM AND OBJECTIVE: To compare the cell proliferative index and to evaluate the role of causative factors among different sub sites of patients with oral squamous cell carcinoma by assessing the cell proliferation by mean AgNOR counts. MATERIALS AND METHODS: This is a prospective study and a total of 94 subjects with histologically proven oral squamous cell carcinoma were included. They were classified into four groups based on the site of the lesion, namely, carcinoma of buccal mucosa (group I), carcinoma of alveolar mucosa (group II), carcinoma of tongue (group III), carcinoma of retromolar trigone area (group IV). Each group was inturn subdivided into subgroups based on the etiological factors. The etiological factors considered in our study were betel quid chewing, mawa or gutka chewing and smoking for group I, group II and group IV and trauma was considered to be an etiological factor for group III. The cell proliferation marker used in this study are the silver-stained nucleolar organizer regions (AgNORs) and mean AgNOR count was used to compare the cell proliferation rate among the four groups and amongst the sub-groups in each group. The results were analysed for statistical significance. RESULTS: The mean AgNOR count for group III (carcinoma of tongue) was significantly higher than the other groups. Amongst the sub-groups of group I (carcinoma of buccal mucosa), sub-group with etiology of smoking showed significantly higher mean AgNOR counts. In case of group III (carcinoma of tongue) sub-group with trauma as the etiological factor showed significantly higher mean AgNOR counts than subgroups with other etiological factors CONCLUSION: Carcinoma of tongue showed greater cell proliferation rate when compared to other subsites of oral cavity considered in this study. Thus greater cell proliferation rate could be one of the reasons for poor prognosis of tongue cancer as established by many other studies. Trauma causes greater cell proliferation rate when compared to other etiological factors in tongue. In buccal mucosa, smoking causes greater cell proliferation when compared to other etiologies. Further studies are required to establish the influence of the site of origin and different etiological factors on cell proliferation rate and hence the prognosis of oral squamous cell carcinomas.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Cell proliferation ; Oral cancer sub-sites ; AgNORs.
Subjects: DENTAL > Oral Pathology and Microbiology
Depositing User: Subramani R
Date Deposited: 12 Nov 2017 13:20
Last Modified: 12 Nov 2017 13:20
URI: http://repository-tnmgrmu.ac.in/id/eprint/3903

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