Vijayachandar, P (2013) Estimation of Serum Beta Carotene in patients with Oral Sub Mucous Fibrosis, Oral Squamous Cell Carcinoma. Masters thesis, Tamil Nadu Government Dental College and Hospital, Chennai.
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Abstract
BACKGROUND: Oral submucous fibrosis is a chronic, debilitating premalignant condition of the oral mucosa which is associated with chewing of areca nut. The etiology and pathogenesis has been studied in detail over the past few decades, but many controversies still persist. Increased oxidative stress associated with disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases, most notably oral cancer. AIM: To estimate the serum beta carotene level in patients with oral sub mucous fibrosis and oral squamous cell carcinoma. MATERIALS AND METHODS: In the present study, totally 180 cases were selected from the Dept. of Oral Medicine and Radiology, Tamilnadu Government Dental College & Hospital. They were divided into three groups. Group I consisted of 60 patients with clinically diagnosed oral sub mucous fibrosis of different stages. Group II consisted of 60 patients with clinically diagnosed and histopathologically proven oral squamous cell carcinoma. Group III was the control group which consisted of 60 normal patients. The age of the patients ranged from 20 to 60 years. The concentration of Beta Carotene present in the serum samples was determined by Bradley and Hornbeck method in Dept. of Biochemistry, Madras Medical College & Hospital. RESULTS: Results were analyzed using one way ANOVA test for comparing the concentration of serum beta carotene level among group I, II and III. The results of our study revealed a significant decrease in the concentration of serum β-carotene level in group II patients (56.46μg/dl) when compared with group I patients (77.54 μg/dl) and group III (120.21μg/dl).In group I, patients were compared using clinical staging wherein stage II showed the highest serum beta carotene level (79.51 μg/dl) and stage III showed a level of 66.32 μg/dl. But when functional staging was compared, stage A had the highest level of serum beta carotene level 82.57 μg/dl, while stage C had the lowest level of 53.30μg/dl and stage B in between the two (67.14μg/dl).In group II patients were compared based on TNM staging, stage II showed the highest value (72.88μg/dl) and was lowest for stage IV (42.31μg/dl). When same patients were compared using histological staging, well differentiated group had the highest level of serum β-carotene 58.63μg/dl with lowest level of 34.29μg/dl for poorly differentiated group. Conclusion: From the present study, we conclude that oral submucous fibrosis and oral squamous cell carcinoma cause a significant reduction in level of serum β-carotene and this decrease correlates well with the disease progression. So Beta carotene can be used for the prevention and to limit the progression of these diseases. Further longitudinal studies with increased sample size are required to substantiate the role of Beta carotene level in precancerous condition and malignancy.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Oral submucous fibrosis ; Oral squamous cell carcinoma ; antioxidants ; β-carotene. |
| Subjects: | DENTAL > Oral Medicine and Radiology |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Nov 2017 07:16 |
| Last Modified: | 12 Nov 2017 07:16 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3897 |
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