Evaluation of Clinical Effectiveness of Platelet Rich Fibrin and Bone Graft in Management of Intrabony Defects: A Comparative Study.

Shruti, Beri (2013) Evaluation of Clinical Effectiveness of Platelet Rich Fibrin and Bone Graft in Management of Intrabony Defects: A Comparative Study. Masters thesis, Tamil Nadu Government Dental College and Hospital, Chennai.


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BACKGROUND : Periodontal therapy aims to prevent periodontal tissue destruction while achieving regeneration of lost and damaged tissues. Demineralized bone matrix (DMBM) is a xenograft with acceptable clinical responses in the field of periodontal regeneration. Platelet Rich Fibrin (PRF) is the latest advancement in fibrin technology and is a rich autologous source of various growth factors and leukocytes. PRF has a strong potential to influence the cellular mechanisms responsible for periodontal regeneration to be achieved. A combination of the two grafting modalities may prove to be an advantageous regenerative treatment option for management of intrabony defects. AIM : The aim of this study was to clinically and radiographically evaluate, the additional effectiveness of autologous PRF, when used in combination with bone graft (DMBM) as compared to bone graft (DMBM) alone, in the treatment of intrabony defects. METHODS : A total of 18 intrabony defects in 15 systemically healthy patients were selected randomly for the purpose of the study. The defects were equally divided into two groups and treated with DMBM alone and in combination with PRF. Clinical parameters such as plaque index (PI), gingival bleeding index (GBI), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at baseline and at 6 months post-operatively. In both the groups, radiographic analysis was performed at baseline, and at 3 months and 6 months post operatively. RESULTS : Significant reduction in post- operative mean pocket depth and gain in attachment level was observed in PRF-DMBM and DMBM groups as compared to baseline. Also, greater attachment gain was observed in PRF-DMBM group postoperatively. Radiographically, at the end of 6 months, reduction in defect depth was significantly greater in PRF-DMBM group than DMBM group (p=0.007). Greater gain in percentage of bone fill was observed for PRF-DMBM group than for DMBM group at 6 months. Percentage of original defect resolution was statistically greater in PRFDMBM group (40.23 ±29.41 %) as compared to DMBM alone (12.43±14.14 %) at 3 months. CONCLUSION : Autologous PRF when added to DMBM demonstrated additional effectiveness and ability to augment the effects of bone graft material, clinically and radiographically in management of periodontal intrabony defects.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Demineralized bone matrix ; Intrabony defect ; Periodontal Regeneration ; Platelet Rich Fibrin.
Subjects: DENTAL > Periodontology
Depositing User: Subramani R
Date Deposited: 12 Nov 2017 07:16
Last Modified: 12 Nov 2017 07:16
URI: http://repository-tnmgrmu.ac.in/id/eprint/3895

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