Ashish George, Kuruvilla (2013) Ocular pulse amplitudes in diabetics in South India. Masters thesis, Christian Medical College, Vellore.
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Abstract
OBJECTIVES: Describe the objectives of your study 1. To document any difference in Ocular Pulse Amplitudes with increasing severity of Diabetic retinopathy. 2. To document any difference in Ocular Pulse Amplitudes between Diabetics with and without systemic Hypertension METHODS: Explain the clinical and statistical methods used This study was a prospective non randomised observational study to look at the ocular pulse amplitudes using dynamic contour tonometry in various stages of diabetic retinopathy and also in patients with Hypertension. Participants were divided into groups based on the presence or absence of Diabetes. There were 3 groups, 50 in each group, namely: 1. No diabetes, 2. Diabetes with no diabetic retinopathy and 3. Diabetes with retinopathy. Participants with retinopathy were further divided into 3 sub groups: mild diabetic retinopathy, moderate diabetic retinopathy and severe non proliferative diabetic retinopathy and proliferative diabetic retinopathy being clumped into the last group Statistical analysis was done mostly with hypothesis testing for 2 means, from which the sample size was calculated. ANOVA was also used. RESULTS: The total number of participants included in the study was 172. 3 Patients, who were screened to be selected in the No DM arm, who were found to have raised HbA1c (>6.5 mg/dl) were taken out of the study and referred to Department of Medicine, CMC Vellore. 4 patients enrolled were not able to sit by the slit lamp for the period of time required and therefore the quality index was not 1 or 2 in these participants. Therefore, they were taken out of the study. One of the patients had a neck ailment and mechanically found it difficult to place her chin on the chin rest on the slit lamp. Though not mentioned in the criteria, she was not selected in the study for obvious reasons. 3 patients refused to undergo blood tests to confirm absence of Diabetes. All three were women. Two of them felt that they were too anaemic for blood tests and the third did not want to be poked repeatedly after the trained nursing staff failed to get a vein in two attempts. Therefore, these 3 women were not included in the study. Conclusions: 1. OPA is reduced in diabetics with severe NPDR and PDR as compared to normals and patients with milder grades of retinopathy 2. Reduced OPA is seen in non- hypertensive patients with diabetic retinopathy as compared to normals and hypertensives with diabetic retinopathy 3. Further studies with larger sample sizes in each grade of diabetic retinopathy is needed to evaluate the exact effect of hypertension in these patients
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Ocular pulse amplitudes; diabetic retinopathy; diabetics |
| Subjects: | MEDICAL > Ophthalmology |
| Depositing User: | Devi S |
| Date Deposited: | 10 Nov 2017 07:02 |
| Last Modified: | 10 Nov 2017 07:02 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3881 |
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