Satya Naveen, Aketi (2012) Formulation and Evaluation of Taste Masked Sumatriptan Succinate Mouth Disintegrating Tablets. Masters thesis, K K College of Pharmacy, Chennai, Tamil Nadu, India.
Full text not available from this repository.Abstract
Oral drug delivery has been known for decades as the most widely utilized route of administration among all the routes that have been explored for the systemic delivery of drugs via various pharmaceutical products of different dosage forms. The reason that the oral route achieved such popularity may be attributed to its ease of administration as well as the traditional belief that by oral administration the drug is well absorbed as the food stuffs ingested daily. In fact, the development of pharmaceutical products for mouth delivery, irrespective of physical form involves varying extents of optimization of dosage form within the inherent constraints of gastro intestinal physiology. Therefore, a fundamental understanding of various disciplines, including gastro intestinal physiology, pharmacokinetics, pharmacodynamics and formulation design are essential to achieve a systemic approach to the successful development of an oral dosage form. The more sophisticated a delivery system, the more is the complexity of these various disciplines involved in the design and optimization of the system. The scientific framework required for the successful development of an oral drug delivery system consists of a basic understanding of the following three aspects: The tablets are prepared by drirct compression by using drug, polymer complex in 1:2, different superdisintegrating agents like crospovidone, croscarmellose sodium, sodium starch glycilate in different percentages like 3%, 4% and 5%. The prepared tablets are evaluated for post compression parameters like wetting time, drug content uniformity, friability, hardness, invitro dispersion time and uniformity of dispersion. The invitro dissolution study was conducted for all formulations which are prepared by different super disintegrating agents like crospovidone, croscarmellose sodium, sodium starch glycilate in different percentages like 3%, 4% and 5%. T50% & T90% for nine formulations were calculated. From the reults, F3 (crospovidone 5%), F6 (croscarmellose 5%) and F9 (Sodium starch glycolate 5%) shows better results. Among this three formulations (F3, F6 and F9), the F3 formulation with 5% crospovidone was found to be the best formulation, superior in activity. From the drug release kinetics sumatriptan succinate follows first order release kinetics because the regression factor of first order is nearer thane the zero order kinetics. Accelerated stability studies on the final formulation indicated that there are no significant changes in thickness, hardness, % friability, wetting time (sec), disintegration time and drug content at the end of one month.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Formulation; Evaluation; Taste Masked; Sumatriptan Succinate; Mouth Disintegrating Tablets |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 24 Jun 2017 10:08 |
| Last Modified: | 24 Jun 2017 10:08 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/388 |
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