Effect of Phase I Therapy on Salivary Carboxyterminal Telopetide of Type I Collagen in Chronic Periodontitis Patients

Kiruthika, S (2013) Effect of Phase I Therapy on Salivary Carboxyterminal Telopetide of Type I Collagen in Chronic Periodontitis Patients. Masters thesis, Tamil Nadu Government Dental College and Hospital, Chennai.


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BACKGROUND: Salivary biomarkers are extensively studied in various fields of dentistry. Carboxyterminal telopeptide of type I collagen (CTX), a degradation product which is a marker of bone resorption is released into tissues during periodontal disease process and reaches the saliva via GCF. Changes in salivary CTX levels can be used to detect and monitor periodontal disease activity. AIM: The aim of the present study is to analyse the effect of phase I therapy in chronic periodontitis subjects by evaluating the salivary CTX levels and to compare and correlate the salivary CTX levels with clinical parameters. MATERIALS AND METHODS: Salivary CTX levels were determined in patients with chronic periodontitis, n=25 (study group) and healthy controls (n=20) using Enzyme linked Immunosorbent Assay (ELISA). The salivary CTX levels were compared and correlated with clinical parameters namely PI, GBI, PPD, CAL before and after phase I therapy. RESULTS: There was statistically significant increase in salivary CTX levels in the study group when compared to the control group (p<0.01), and these levels reduced significantly after treatment. Positive correlation was shown between the clinical parameters and salivary CTX levels but the correlation was not significant in both the groups (p>0.05). CONCLUSION: In the present study, there was a significant difference in salivary CTX levels between the groups and a significant decrease in these levels was observed after phase I therapy in the study group. This signifies that the detection of CTX in saliva may be useful to detect individuals at risk, the periodontal disease activity and its response to periodontal therapy.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Carboxyterminal telopeptide of type I collagen (CTX); bone resorption markers ; chronic periodontitis.
Subjects: DENTAL > Periodontology
Depositing User: Subramani R
Date Deposited: 10 Nov 2017 01:44
Last Modified: 11 Nov 2017 16:22
URI: http://repository-tnmgrmu.ac.in/id/eprint/3866

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