Molecular detection of New Delhi metallobetalactamases in escherichia coli and klebsiella pneumoniae in clinical isolates of a tertiary care hospital

Uma Maheswari, M (2015) Molecular detection of New Delhi metallobetalactamases in escherichia coli and klebsiella pneumoniae in clinical isolates of a tertiary care hospital. Masters thesis, PSG Institue of Medical Sciences and Research, Coimbatore.

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Abstract

Enterobacteriaceae are inhabitants of human, animal gastrointestinal tract and various other environmental sites.Escherichia coli and klebsiella pneumoniae initially responded to betalactam antibiotics but there was an increase in resistance to betalactam antibiotics due to beta lactamase produced by them. Resistance to carbapenems has now become more prevalent due to production of carbapenemases. NDM-1 is a novel metallo betalactamase that is capable of hydrolysing all beta lactam antibiotics except Aztreonam NDM-1 was detected in 82% 0f samples. Appropriate detection of emerging mechanism of resistance will prevent unnecessary mortality and morbidity. Carbapenamase carrier state was 8% and the less incidence is probably due to the infection control measures.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Newdelhi Metallobetalactamases (NDM1) ; escherichia coli ; klebsiella pneumoniae ; Intensive care unit (ICU).
Subjects: MEDICAL > Microbiology
Depositing User: Punitha K
Date Deposited: 23 Jun 2017 12:11
Last Modified: 09 Dec 2018 04:05
URI: http://repository-tnmgrmu.ac.in/id/eprint/382

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