Isolation, characterization and antibiotic susceptibility pattern of haemophilus influenzae in a Tertiary care hospital

Sai Keerthana, D (2015) Isolation, characterization and antibiotic susceptibility pattern of haemophilus influenzae in a Tertiary care hospital. Masters thesis, PSG Institue of Medical Sciences and Research, Coimbatore.

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Abstract

Haemophilus influenza is strictly a human pathogen responsible for many diseases like community acquired pneumonia, meningitis, sinusitis, epiglottitis and otitis media. Haemophilus type b is the most common strain responsible for all the infections. Non type able strains are at emerging risk. Ampicillin resistance is being reported and is due to production of betalactamases. Ampicillin resistance is being reported and is due to production of betalactamase, but rarely can also be due to aminoacid substitutions in the Penicillin binding proteins (PBP) which is known as BLNAR Out of 103 Haemophilus influenzae isolates, majority of them were isolated from elderly male patients (49%) and show higher incidence during the winter months. Due to the vaccination available against type b Haemophilus influenzae, Non type b Haemophilus influenzae shows higher risk (67%) when compared to type b (33%). None of the cases of type b is seen in children below 5 years of age. Haemophilus influenzae shows higher sensitivity pattern to ceftriaxone (91%), Azithromycin (96%)and Tetracycline (97%). There is no difference in the susceptibility to drugs between type b and Non type b isolates. Beta lactamase positive H. influenzae were seen in 15 isolates. Out of them, 13 showed TEM-1 beta lactamase gene by PCR.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Satellitism ; XV Factor Requirement ; Porphyrin Synthesis Test ; Fildes Agar ; TEM-1.
Subjects: MEDICAL > Microbiology
Depositing User: Punitha K
Date Deposited: 23 Jun 2017 12:06
Last Modified: 09 Dec 2018 04:01
URI: http://repository-tnmgrmu.ac.in/id/eprint/378

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