Devi, M (2014) Evaluation of In-Vitro and In-Vivo Antiurolithiatic Activity of Various Extracts of Whole Plant of Azima Tetracantha Lam. on Ethylene Glycol Induced Urolithiasis in Rats. Masters thesis, Institute of Pharmacology, Madras Medical College, Chennai.
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Abstract
In the present study, plant such as Azima tetracantha Lam. was selected for evaluate its antiurolithiatic activity. Experimental Animals: The present study was conducted after obtaining approval from the Institutional Animal Ethics Committee and this protocol met the requirements of national guidelines of CPCSEA (PROPOSAL NO: Vide. 14/243/CPCSEA). The Wistar albino rats (150-200g) used for this study were procured from Animal house, Madras Medical College, Chennai, India. AIM & OBJECTIVE: To identify the active phytochemical components in the whole plant extract of Azima tetracantha To determine the Calcium oxalate crystallization inhibition by in-vitro method. To investigate the in-vivo anti urolithiatic effect of various extract of Azima tetracantha Lam. in Ethylene glycol induced urolithiasis in Wistar albino rats. CONCLUSION: From the present study we conclude that the preliminary phytochemical analysis of Azima tetracantha Lam. indicated the presence of Alkaloids, Flavonoids, Proteins, Saponins, Terpenoids, Phytosterols, Carbohydrates and Fatty acids. In-vitro Calcium oxalate crystallization inhibition study was evaluated. From this study we conclude that the ethanol, ethyl acetate, chloroform and pet.ether extracts of Azima tetracantha Lam. inhibits the calcium oxalate crystallization in the order of 82%, 75%,66% and 55% respectively. In-vivo Anti urolithiatic activity of various extracts (Ethanol, Ethyl acetate, Chloroform and Pet.ether) of Azima tetracantha Lam. was evaluated and we conclude that the ethanol and ethyl acetate extracts of the plant Azima tetracantha Lam. produced significant antiurolithiatic activity like that of standard. Moderate effect was produced by chloroform extract.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | In-Vivo Antiurolithiatic Activity; Azima Tetracantha Lam; Ethylene Glycol Induced Urolithiasis in Rats. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 20 Oct 2017 07:26 |
| Last Modified: | 20 Oct 2017 07:26 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3748 |
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