Pharmacological Evaluation of Canthium Coromandelicum (Burm.F) Alston in Experimental Animal Models

Prasath, R (2014) Pharmacological Evaluation of Canthium Coromandelicum (Burm.F) Alston in Experimental Animal Models. Masters thesis, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil.

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Abstract

The present study Canthium coromandelicum is used traditionally for the treatment of diseases like HIV, diseases produced by micro organism , Diabetics, etc and is known as reputed drug of ayurveda. Our aim is to prepare the methanolic and aqueous extract of the leaves Canthium coromandelicum and to perform biological screening to elucidate the therapeutic potential of the plant considering their traditional usage, the following objectives are: Qualitative phyto chemical evaluations of Canthium coromandelicum, Hepatoprotective model and Diuretic model. CONCLUSION: HEPATOPROTECTIVE ACTIVITY : The hepatoprotective effect of aqueous and methanolic extract of Canthium coromandelicum leaves was confirmed by the following measures: The isolated livers from the toxicant (paracetamol) treated animals exhibited increase in wet liver weight. Indeed, extract treated animals exhibited decrease in the values of above physical parameters as an indication of hepatoprotection. Serum marker enzymes such as SGPT, SGOT and total bilirubin, showed marked increase. The same is observed in liver diseases in clinical practice and hence are having diagnostic importance in the assessment of liver function. In the present study, the methanolic and aqueous extract of Canthium coromandelicum leaves significantly reduced the elevated levels of above mentioned serum marker enzymes. Hence, at this point it is concluded that the methanolic and aqueous extract of Canthium coromandelicum leaves possesss hepatoprotective activity. In support to this study, histopathological results also show significant activity of the plant. In toxicant treated animals there will be severe disturbances in the cytoarchitecture of the liver. The same is observed in case of humans who are suffering from major liver disorders. But in the methanolic and aqueous extract of Canthium coromandelicum leaves treated group animals exhibited minimal hepatic derangements and intact cytoarchitecture of the liver was maintained. In addition to this there is regeneration of hepatocytes also observed, which indicating hepatoprotective activity. Finally based on improvement in serum marker enzyme levels, physical parameters, functional parameters and histopathological studies, it is concluded that the methanolic and aqueous extract of Canthium coromandelicum leaves possesses hepatoprotective activity and thus supports the traditional application of the same under the light of modern science. DIURETIC ACTIVITY : The diuretic effect of aqueous and methanolic extract of Canthium coromandelicum leaves was confirmed by the following measures: The urine levels and electrolyte levels such as sodium and potassium levels from the frusemide treated animals exhibited increased in above levels. Indeed, the aqueous and methanolic extract of Canthium coromandelicum leaves extract treated animals exhibited the significantly same in urine levels and electrolyte levels. Hence, at this point it is concluded that the aqueous and methanolic extract of Canthium coromandelicum leaves possesss diuretic activity.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Pharmacological Evaluation ; Canthium Coromandelicum (Burm.F)Alston ; Experimental Animal Models.
Subjects: PHARMACY > Pharmacology
Depositing User: Ravindran C
Date Deposited: 20 Oct 2017 07:20
Last Modified: 22 Dec 2018 09:18
URI: http://repository-tnmgrmu.ac.in/id/eprint/3729

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