Evaluation Changes of Lungs in Asthmatic Rats Treated with Aqueous and Non Aqueous Extract of Clerodendrum Serratum and Theophylline.

Siva Kumar, G M (2014) Evaluation Changes of Lungs in Asthmatic Rats Treated with Aqueous and Non Aqueous Extract of Clerodendrum Serratum and Theophylline. Masters thesis, Cherraan’s College of Pharmacy, Coimbatore.

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The present study Asthma is one of the common disorders encountered in clinical medicine in both adults and children are asthma and it is characterized by inflammation of the airways which causes airway dysfunction. Asthma is currently a worldwide problem with around 300 million people around the global suffering from it and world deaths of about 25000 annually. Inhaled bronchodilators and anti inflammatory drugs are available and effective and they require long term use and are associated with side effects. This is why alternative and complementary medicine is being sort after to prevent these side effects. Several medicinal plants have anti inflammatory effect and have proved effective in the treatment of asthma. Clerodendrum serratum Linn (Family-Verbenaceae) is very widely distributed in tropical and subtropical regions of the world. Citric acid, Acetylcholine, Histamine is mainly used for evaluating anti asthmatic activity of particular drug. This review contains list of medicinal plant which have been tested for anti asthmatic activity in the Citric acid, Acetylcholine induced asthmatic in Rat model Thus, the information provided in this research will help the researchers for the development of an alternative methods rather than inhalers and oral anti asthmatic drugs for the treatment of asthma and COPD which will minimize the complication. Many plants obtained from the natural source play a significant role in the health care system. Literature survey on herbal drugs has shown significant anti asthmatic activity which has not shown any remarkable side effect. The pharmacological mechanism which the phyto constituents producing the anti asthmatic activity are not clearly understood till date. The several herbal formulation have derived from the Ayurveda, traditional system of Indian medicine and its additional system of medicine, yet to be scientifically validated that they have exhibited pharmacological action against Asthmatic. Only less number of scientific data of traditional medicines is available for the treatment of Asthmatic. CONCLUSION: On the basis of the result in these experiments, this may be stated that the aqueous extract of Clerodendrum serratum 200mg/kg has a beneficial effect in asthmatic patients. It will reduce the alveolar thickness and Eosinophils counts in blood further studies are required to purify the active principle and to study the molecular mechanism of the exact pathway. Non aqueous extract of Clerodendrum serratum (400mg/kg) having fewer amounts of steroids and flavonoids because it will filter the all compounds and reduce the quantity of chemical moieties. But aqueous extract of Clerodendrum serratum (200mg/kg) having higher amount of chemicals when compare to Non aqueous extract of Clerodendrum serratum (400mg/kg) so it will produce anti asthmatic at equal to standard drug. In lungs alveolar thickness reduced by the AECS 200mg/kg as equal to standard drug and also it’s same as normal lungs. So aqueous extract of Clerodendrum serratum having good beneficial effect for the asthmatic patients. This information’s will be useful for the development of alternative method rather than anti asthmatic agents (Inhalers, Tablets, Injections, Nasal sprays, Respules) for the treatment of Asthmatic patients. This will minimize the wheezing and or asthmatic symptoms.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Asthmatic Rats; Aqueous; Non Aqueous Extract; Clerodendrum Serratum; Theophylline
Subjects: PHARMACY > Pharmacology
Depositing User: Ravindran C
Date Deposited: 20 Oct 2017 07:19
Last Modified: 20 Oct 2017 07:19
URI: http://repository-tnmgrmu.ac.in/id/eprint/3728

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