Arivazhagan, N (2014) Phytochemical and Pharmacological Evaluation of Ethanolic Extract of Lawsonia Inermis. Masters thesis, Cherraan’s College of Pharmacy, Coimbatore.
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Abstract
The present study Liver disease are the biggest threat to the world which is characterised with impaired metabolic secretary function of liver clinically as jaundice, cirrhosis, hepatitis, liver cancer and ultimately liver failure. About 20,000 deaths founds every year due to liver disorders. A common chronic disease known as liver fibrosis may lead to end-stage cirrhosis and liver cancer. Hepatocellulor carcinoma is the one of the ten most common tumers in the world with over 2,50,000 new cases each year. In the treatment of liver diseases in modern medicine cartico steroids and immunosuppressants are commonly used to treat to liver disease in allopathic form of medicine. But these drugs are associated with adverse effects such as immunosuppression and bone marrow depression. Further, the success rate of treating liver diseases is disappointing. Attempts are being made globally to get scientific evidence for this traditionally reported herbal drugs. Lawsonia inermis L. belonging to the family of lythraceae. A shrub commonly known as mehendi and henna. Mainly the aim of the study was evaluate the hepatoprotective activity as evidence from the literature review. The lawsonia inermis is traditionally used in india for the treatment of jaundice, enlargement of liver and spleen. It has been reported to possesses the anti-inflammatory, anti-microbial and anti-cancer activity. Because the one of the major active component of the leaves of lawsonia inermis are flavanoids. The hepatoprotective activity of warm aqueous extract of leaves of lawsonia inermis has been reported. But detail study of hepatoprotectivity has not done. The present study has been undertaken with aim to determine the hepatoprotective activity of ethanolic extract of lawsinia inermis in animal model by estimating biochemical and histopathalogical parameters. CONCLUSION: The hepatoprotective effect of ethanolic extract of lawsonia inermis leaves was confirmed by the biochemical and histopathalogical studies. In biochemical studies serum marker enzymes such as SGOT, SGPT, ALP, bilirubin showed marked increase and decrease in the level of protein. The same is observed in liver disease in clinical practice and hence are having diagnostic importance in the assessment of liver function test. In the present study, the ethanolic extract of lawsonia inermis leaves significantly reduced the elevated levels of above mensioned serum marker enzymes and increase in the level of protein. Hence at this point concluded the ethanolic extract of lawsonia inermis leaves posses hepatoprotective activity. In support to this study, histopathalogical results also show significant activity of the plant. In toxicant treated animals there will be severe disturbances in the cytoarchitecture of the liver. But in ethanolic extract of lawsonia inermis leaves treated group animals exhibited minimal hepatic dearrangrments and intact cytoarchitecture of the liver was maintained. In addition to this there is regeneration of hepatocytes also observed, which indicating hepatoprotective activity. Finally based on the improvement in serum marker enzyme level, and histopathalogical studies. It is concluded that the ethanolic extract of lawsonia inermis leaves posses hepatoprotective activity.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Phytochemical; Pharmacological Evaluation; Ethanolic Extract; Lawsonia Inermis |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 20 Oct 2017 07:15 |
| Last Modified: | 20 Oct 2017 07:15 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3727 |
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