Sathiyaraj, C (2014) Design, Synthesis, Characterization and Biological Evaluation of Some Novel Butyrolactone Derivatives of Chalcone as Antitubercular Agents. Masters thesis, College of Pharmacy, Madras Medical College, Chennai.
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Abstract
AIM: The present study of this project is to develop potential antimycobacterial agents. OBJECTIVES: The objective of the project is to design and synthesize some compounds which will act on L, D Transpeptidase 2 and inhibit the cell wall synthesis of M.tuberculosis. THE PLAN OF WORORK: Design of L, D Transpeptidase 2 inhibitors by docking studies Insilico Prediction of Drug Likeness and Toxicity Laboratory synthesis of the top G score compounds Characterization of the synthesized compounds by Infrared Spectroscopy Nuclear Magnetic Resonance Spectroscopy Mass Spectroscopy In-vitro anti tubercular activity of synthesized compounds. CONCLUSION: It is thus concluded that the synthesized compounds might effectively inhibit the chosen target, L, D Transpeptidase 2 which is crucial for the growth of Mycobacterium tuberculosis. These molecules can be further modified structurally and more prospective potential molecules against the Mycobacterium tuberculosis can be developed.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Novel Butyrolactone Derivatives; Chalcone; Antitubercular Agents |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 20 Oct 2017 07:01 |
| Last Modified: | 20 Oct 2017 07:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3715 |
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