Hemalatha, P V (2012) Validated Method Development for the Quantification of Cinitapride and Pantoprazole by Spectrophotometry and RP-HPLC in Bulk and Oral Dosge form. Masters thesis, College of Pharmacy, Madras Medical College, Chennai.
|
Text
26108332 Hemalatha P V.pdf Download (2MB) | Preview |
Abstract
The present study analysis of drugs plays a major role in the development, manufacture and therapeutic use of drug. Quantitative analysis of raw materials and the final product is necessary to ensure that they meet certain specifications and to ascertain the amount of each component in the final product. Standard analytical procedures for newly designed and synthesized drugs are not available in any of the pharmacopoeias. So it becomes necessary to develop newer, accurate, specific, simple, easy to perform, reliable and economic analytical techniques for the estimation of the new drugs. This thesis deals with pantoprazole (PNP) and cinitapride (CNP). Pantoprazole has been recently included in Indian Pharmacopoeia – 2010. Cinitapride is a very new drug, launched in 2007 and is not official in any of the pharmacopoeias. It has been very recently added in drug bank in 2012. The combination of the two drugs has been launched in 2011.Extensive literature survey reveals that only first derivative and HPTLC method for the determination of pantoprazole (PNP) and cinitapride (CNP) has been reported. There is no evidence for the estimation of PNP and CNP by UV-Visible spectrophotometry and RP-HPLC. CONCLUSION: The developed UV – Visible and RP-HPLC methods were found to be simple, precise, accurate and rapid methods for the analysis of Cinitapride and Pantoprazole in its pure form and in its pharmaceutical dosage formulation. Thus, all the above adopted methods can be effectively used for the routine analysis of Cinitapride and Pantoprazole in pharmaceutical dosage form. methods in bulk and in combined tablet dosage form. So, an attempt has been made is to develop a validated, simple, easy to perform, accurate, cost effective and rapid spectrophotometric methods for the estimation of CNP and PNP in bulk and combined oral dosage form.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Cinitapride; Pantoprazole; Spectrophotometry; RP-HPLC; Oral Dosge form |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 20 Oct 2017 06:42 |
| Last Modified: | 20 Oct 2017 06:42 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3704 |
Actions (login required)
 |
View Item |
