Synthesis, Characterization of Flavonol Derivatives and it’s Biodynamic Activities and Associated Parameters.

Shinde Akshay, Rajendra (2012) Synthesis, Characterization of Flavonol Derivatives and it’s Biodynamic Activities and Associated Parameters. Masters thesis, Nandha College of Pharmacy and Research Institute, Erode.

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The present study Current approaches in the treatment of hyperglycemia involve drug treatment with various classes of anti-diabetics. Major drawbacks of chemotherapy include adverse effects and drug resistance. Adverse effects associated with traditional anti diabetic drugs are hepatotoxicity and severe hypoglycemia. Therefore to overcome the shortcomings of the present treatment, an anti hyperglycemic drug with a new mechanism of action, capable of providing complete and safe treatment of diabetics mellitus. Drug designing is an important tool in the field of medicinal chemistry wherein the syntheses of new medicinal compounds are done by molecular or chemical manipulation of the lead moiety in order of producing a highly active compound. Thus, making gradual changes in physio-chemical properties of the lead moiety to enhance the biological activities. Literature survey reveals that 3-Flavonols are well known for their varied pharmacological activities. In view of the above mentioned facts and continuation of our work on the synthesis of biologically important Flavonoids compounds and to screen further following scheme. The present study on the evaluation of 4-flavones derivatives (flavanol) were found in significant activity of in vitro and in vivo anti-inflammatory, anti-microbial and anti-hyperglycemic. The study of flavonoids is complex because of the heterogeneity of the different molecular structures and the scarcity of data on bioavailability. Furthermore, insufficient methods are available to measure oxidative damage in vivo and the measurement of objective endpoints remains difficult. There is a need to improve analytic techniques to allow collection of more data on absorption and excretion. Data on the long-term consequences of chronic flavonoid ingestion are especially scarce. In conclusion, the in vivo studies that have been performed do give a hopeful picture for the future On the basis of order of pharmacological studies of test compounds the following structure activity relationship (SAR) was observed At C-2, p-nitrophenyl, p-chlorophenyl, p-methoxyphenyl, p-hydroxyphenyl substitution showed the best activity followed by furyl substitution. Non substitution of flavonol ring at C-7 was less favorable for the activity than C-7 methoxy and 6,8 di-iodo substitution and At C-4’ substitution of C-2 phenyl ring was more favorable.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Synthesis; Biodynamic Activities; Associated Parameters
Subjects: PHARMACY > Pharmaceutical Chemistry
Depositing User: Ravindran C
Date Deposited: 20 Oct 2017 06:40
Last Modified: 20 Oct 2017 06:40

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