Comparison on Efficacy and Safety of Linagliptin Vs. Sitagliptin Among Type 2 Diabetic Patients.

Anbarasan, V (2014) Comparison on Efficacy and Safety of Linagliptin Vs. Sitagliptin Among Type 2 Diabetic Patients. Masters thesis, Ultra College of Pharmacy, Madurai.

261240251 Anbarasan V.pdf

Download (3MB) | Preview


AIM: The present study was to compare the efficacy and safety of linagliptin with that of sitagliptin among type 2 diabetic patients. OBJECTIVE: To assess the comparative efficacy of the DPP-4 inhibitors linagliptin/sitagliptin through, Fasting plasma glucose (FPG), post prandial glucose (PPG) and glycated haemoglobin (HbA1c) levels along with lipid profile and BMI measure in a period of 6 months. � To evaluate and compare the safety of the linagliptin/sitagliptin drugs by following the assessment of renal profile, hepatic profile (Liver Function Test). PLAN OF WORK: The present dissertation work was planned to conduct a “comparative study on efficacy and safety of linagliptin vs. sitagliptin drugs in the treatment of type 2 diabetes mellitus”. And was planned to conduct in Annamalai diabetic research center at Karaikudi. CONCLUSION: The results from the comparative study to evaluate the efficacy and safety of linagliptin and sitagliptin drugs. � The present study shows that two drugs such as linagliptin and sitagliptin reduced the fasting plasma glucose, post prandial plasma glucose and glycosylated haemoglobin level. But the linagliptin provided superior control of glycemic as compare to sitagliptin. There were no significant changes in BMI on both drugs.So linagliptin and sitagliptin had good body weight control. There were favorable changes in lipid profiles in that linagliptin more favorable than sitagliptin. Our study shows that insignificance of renal (Sr.Cr, BU, SUA) and hepatic (TB, ALT, AST) profile. So both drugs were considered to be more safe. It can be concluded with the results of the present study linagliptin possesses greater efficacy with increased glycemic control and good safety compared to sitagliptin in Type 2 diabetic patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Linagliptin Vs Sitagliptin; Type 2 Diabetic Patients
Subjects: PHARMACY > Pharmacy Practice
Depositing User: Ravindran C
Date Deposited: 20 Oct 2017 05:37
Last Modified: 20 Oct 2017 05:37

Actions (login required)

View Item View Item