Sam Pushparaj, C (2014) A Comprehensive Study on the Zidovudine Induced Anemia in Aids Patients. Masters thesis, J.K.K. Nataraja College of Pharmacy, Komarapalayam.
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Abstract
AIM AND OBJECTIVE: The present study was to evaluate the basic hematological parameters of the persons developing anemia due to zidovudine and to understand the effect of zidovudine on haematogenesis and to explore alternate possible medications. The purpose of this study was to analyze the drug profile in related to laboratory test and clinical data to determine when starting ARV therapy, stopping or changing therapy because of either side-effect/toxicity or treatment failure. SUMMARY AND CONCLUSION: Seven different patients were studied who were confirmed HIV positive by ELISA and Western blot assay. The literature review showed that works have been performed in AIDS patients, especially in other parts of India, this study have attempted in Tamilnadu. All the patients under this study were on Anti-retroviral therapy. After 3 months of treatment, they presented with different symptoms like fatigue, swelling of legs etc…, Various haematological analysis were performed and conditions like Anemia, Neutropenia, increase level of liver enzymes (SGOT & SGPT) and rarely thrombocytopenia was reported. Based on their reports they were given different treatments including blood transfusion and antiretroviral therapy was changed. After 2 weeks and 6 weeks, haematological parameters were analysed again and was found that there was improvement in haemoglobin and other parameters. The observations and findings clearly indicated that the improvement in haematological parameters was due to changeover of drug Zidovudine to Stavudine and confirmed that Anemia which existed in all patients studied was induced by Zidovudine. Out of 7 patients studied, Neutropenia, hrombocytopenia, increased level of SGOT and SGPT was not found in all patients, but Anemia existed in all patients with a drastic reduction in Hemoglobin and was improved to an extent after changeover of antiretroviral drug regimen.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Zidovudine ; Anemia ; Aids Patients. |
| Subjects: | PHARMACY > Pharmacy Practice |
| Depositing User: | Ravindran C |
| Date Deposited: | 20 Oct 2017 05:36 |
| Last Modified: | 18 Dec 2017 05:35 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3697 |
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