Prasanth, K (2013) Comparative Study on Efficacy of Losartan Versus Telmisartan in Hypertensive Patients. Masters thesis, Ultra College of Pharmacy, Madurai.
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Abstract
The present study was to compare the efficacy of Losartan potassium and Telmisartan, both are belongs to the above mentioned class of angiotensin receptor blockers (ARBs). Of the above Losartan potassium is the prototype and Telmisartan is a newly introduced ARB. AIM: The aim of the present study was to compare the efficacy of Losartan potassium 50 mg Vs Telmisartan 40 mg in patients with hypertension. OBJECTIVE: PRIMARY: To compare the efficacy of Losartan potassium 50 mg Vs Telmisartan 40 mg To assess the mean change in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) with Losartan potassium and Telmisartan in a treatment period of three months. SECONDARY: To assess the mean change in Fasting Blood Sugar (FBS) and Post Pradinal Blood Sugar (PPBS). CONCLUSION: In this present prospective observational study, treatment of hypertension with two study drugs losartan potassium 50 mg and telmisartan 40 mg were carried out in a population of 60 patients. They were instructed to follow a healthy diet with proper exercise. After 3 months study it is observed that, both of the study drugs have good impact on blood pressure lowering. But the Telmisartan 40 mg showed superior reduction in blood pressure when compare to Losartan potassium 50 mg. The second objective of the study ie; effect of study drugs Losartan potassium 50 mg and telmisartan 40 mg in blood sugar levels of population on diabetic therapy. The FBS and PPBS were the parameters observed for the study, there was reduction in FBS and PPBS values in both Group A Group B. And it is observed that the reduction is higher in Group B when compare with Group A. It can be suggested that the partial PPAR gamma agonist activity of Telmisartan accounts for the higher reduction in blood sugar levels.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Losartan Versus; Telmisartan; Hypertensive Patients |
| Subjects: | PHARMACY > Pharmacy Practice |
| Depositing User: | Ravindran C |
| Date Deposited: | 20 Oct 2017 05:34 |
| Last Modified: | 20 Oct 2017 05:34 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3695 |
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