Role of Immunohistochemistry in the Early Detection of Gastrointestinal Lymphomas with Special Reference to Lymphoplasmacytic Infiltrate.

Mohan, K R (2007) Role of Immunohistochemistry in the Early Detection of Gastrointestinal Lymphomas with Special Reference to Lymphoplasmacytic Infiltrate. Masters thesis, Stanley Medical College, Chennai.

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Abstract

Extranodal Lymphomas Account For About 40% Of All Lymphoid Neoplasms And The Most Common Site Is The Gastrointestinal Tract. The Majority Arise Primarily In The Gut However A Minority Of Gut Lymphomas Is A Result Of Secondary Dissemination From Other Nodal Or Extranodal Sites. In Most Instances The Diagnosis Is Established By Endoscopic Biopsies Or Core Biopsies And Histological Interpretation Is Often Challenging. The Common Diagnostic Problem In Diagnosis Of GI Lymphoma Is The Differential Diagnosis Of Reactive Lymphoid Hyperplasia And Lymphoma. Often This Requires A Series Of Advanced Techniques Like Immunohistochemical Staining, PCR Technique And Flow Cytometry To Identify The Monoclonality Of The Lesion. An Interesting Feature Is The Distribution Of Lymphomas In The GIT That Is Paradoxical Since Relatively Few Lymphomas Arise In The Terminal Ileum Where There Is Greatest Concentration Of Lymphoid Tissue And Majority Arise In The Stomach Where There Is No Lymphoid Tissue. So Any Lesion With Lymphocytic Infiltration In GIT Should Be Carefully Examined And Lymphoma Should Be Excluded By One Way Or The Other Before Diagnosing As Benign Reactive Or Inflammatory Lesion. This Dissertation Deals With The Role Of Immunohistochemical Staining With CD3, CD20, CD 45 And Cytokeratin AE1/AE3 Markers In The GI Lesions Which Showed Dense Lymphocytic Infiltration And In Which The Lymphoma Should Be Ruled Out.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Immunohistochemistry ; Early Detection Gastrointestinal Lymphomas; Special Reference Lymphoplasmacytic Infiltrate
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 23 Jun 2017 11:30
Last Modified: 23 Jun 2017 11:30
URI: http://repository-tnmgrmu.ac.in/id/eprint/369

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