Divya, M (2015) Iodine nutritional status in children with acquired hypothyroidism. Masters thesis, Madras Medical College, Chennai.
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Abstract
Hypothyroidism causes significant growth and mental retardation. The existing Universal Salt Iodization program has led to the reduction in Iodine Deficiency Disorders in endemic population groups. Inspite of this, prevalence of goiter is 13%, childhood hypothyroidism is 3% and Subclinical hypothyroidism is 10% in our country. Experience from southeast Asian countries also shows increase in detection of Juvenile autoimmune thyroiditis in post –iodization assessment. Urinary iodine is the prime indicator of a person’s iodine nutritional status. Hence this study is done to assess the iodine nutritional status in children with acquired hypothyroidism and healthy school children. Objectives Primary Objective To find out the iodine nutritional status in children with acquired hypothyroidism of age 2-12 years attending tertiary care centre Secondary Objective To assess changes in iodine nutritional status in autoimmune thyroiditis Study Method Descriptive study Study Population 61 cases of acquired hypothyroidism and 102 healthy children from 2 different schools in Chennai. Materials and Methods Children with acquired hypothyroidism of age 2-12 years attending a tertiary care center were evaluated with history, clinical examination, goiter grading, antithyroid antibody levels, urinary iodine levels, ultrasound and FNAC thyroid gland if goiter is present. Urinary iodine levels were assessed in 102 healthy schoolchildren. If the iodine levels were more than adequate, >200μg/l they were further evaluated with thyroid function tests, antiTPO antibody and Thyroglobulin antibody levels. Results The mean urinary iodine level in cases were 440.2 and 789.9 in healthy school children. Female : Male ratio was 2.7:1. Ultrasound is as sensitive as FNAC in diagnosing thyroiditis. Conclusion Autoimmune thyroiditis is the most common cause of acquired hypothyroidism. Iodine deficiency is no longer the cause of hypothyroidism. There is no correlation between urinary iodine levels and antithyroid antibody levels.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Urinary Iodine Levels; Anti TPO Antibodies; Anti Thyroglobulin Antibodies; Autoimmune Thyroiditis |
| Subjects: | MEDICAL > Paediatrics |
| Depositing User: | Punitha K |
| Date Deposited: | 13 Oct 2017 07:49 |
| Last Modified: | 13 Oct 2017 07:52 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3672 |
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