Shanthi, M (2015) A study of Drug Utilization pattern and adverse drug reaction profile of antidiabetic drugs in patients attending a teaching hospital. Masters thesis, Sree Mookambika Institute of Sree Mookambika Institute of Medical Sciences, Kulasekharam.
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Abstract
To study the utilization pattern, rationality, prescription by brand name or generic name, adverse drug reaction profile and pharmacoeconomic analysis of antidiabetic drugs Materials and Methods: A cross-sectional study was done for a period of one year (between August 2013 to August 2014) at outpatient department of Medicine, Sree Mookambika Institute of Medical Sciences, Kulasekharam, Kanyakumari District, Tamil Nadu. Results: 169 prescriptions were evaluated during the study period. DM was predominant among the female population in this region. Demographic details of the patient included in the study were mean weight 67.56 kg, mean height 155 cm and average body mass index 27.82 kg/m2. All the patients were 1 | Page Abstract diagnosed as type 2 DM and majority being known case of DM. Systemic hypertension was the frequently encountered co-morbid conditions associated with DM. Metformin was the drug chosen for managing DM as monotherapy. 73% of the patients were on combination of antidiabetic drugs. Glimepiride with metformin was the two drug combination therapy frequently prescribed during the study period. Adverse drug reactions reported during the study were hypoglycemia, gastrointestinal discomfort, edema, rashes and myalgia. Majority of ADRs assessed were probable by WHO scale and possible by Naranjo scale. Modified Schumock and Thornton scale assessed many ADRs to be not preventable. As per the modified Hartwig and Siegel scale none of the ADRs were severe. Pharmacoeconomic analysis identified that drugs prescribed by brand name were costlier compared to generic equivalent. Various antidiabetic drugs were prescribed during the study period in which least expensive was glibenclamide and most expensive was sitagliptin. Conclusion: Utilization of antidiabetic therapy in this region has shown a changing trend compared to the previous studies. There is a gradual increase in the prescription of metformin and dramatic increase in the use of newer drugs like pioglitazone, voglibose and sitagliptin. Adverse effect more noted in our study was hypoglycemia. Glibenclamide was the least expensive while sitagliptin was the most expensive in this study.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Drug Utilization Pattern; Adverse Drug Reaction; Antidiabetic Drugs |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Punitha K |
| Date Deposited: | 12 Oct 2017 09:52 |
| Last Modified: | 12 Oct 2017 09:52 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3665 |
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