Nisha Maheswari, Y (2015) Comparison between antiproteinuric effects of cilnidipine and amlodipine as add on therapy in hypertensive patients with chronic renal disease. Masters thesis, Tirunelveli Medical College, Tirunelveli.
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Abstract
To compare the efficacy and safety of cilnidipine and amlodipine as add on therapy in chronic kidney disease patients who are on losartan (Angiotensin receptor blocker) for > 2 months. METHODS: In this prospective, single centered, open labeled, randomized study, the antiproteinuric effects of cilnidipine (L/N type calcium channel blockrer) and amlodipine (L type calcium channel blocker) were examined in diabetic chronic renal disease patients with hypertension (BP ≥ 130/80 mmHg) who are already under treatment with T. Losartan 50 mg OD. Antiproteinuric effects were assessed by reduction in spot urine protein creatinine ratio from baseline. RESULTS: Patients received cilnidipine (n=46) or amlodpine (n=50) for 6 months. Cilnidipine and amlodipine reduced systolic and diastolic blood pressure equally. The spot urine protein creatinine ratio values for cilnidipine and amlodipine were 1.94±1.22 g/g and 1.38±0.98 g/g respectively before treatment and 1.09±0.72 g/g and 1.40±0.65 g/g respectively after treatment. The mean serum creatinine concentration gradually increased in both the groups and attained statistical significance at the end of 6 months. Estimated GFR was maintained by both the drugs throughout the study period. Distribution of CKD stages were also similar between the two groups before and after treatment. None of the produced reflex tachycardia. CONCLUSION: In conclusion, cilnidipine has antihypertensive effect equivalent to amlodipine but addition of cilnidipine rather than amlodipine to losartan decreased urine protein excretion in diabetic chronic kidney disease patients. Therefore combination therapy with cilnidipine and RAS inhibitor may be more beneficial and renoprotective in patients with diabetic chronic kidney disease.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | L/N type Calcium Channel Blocker; L type Calcium Channel Blocker; Angiotensin Receptor Blocker; Diabetic Chronic Kidney Disease/Chronic renal disease, Hypertension, Urine protein creatinine ratio, antiproteinuric effects. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Punitha K |
| Date Deposited: | 12 Oct 2017 06:53 |
| Last Modified: | 12 Oct 2017 06:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3660 |
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