Subbiah, - (2014) Formulation and Evaluation of Amoxicillin and Potassium Clavulanate Dispersible Tablet. Masters thesis, C. L. Baid Metha College of Pharmacy, Chennai.
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Abstract
This research work is to formulate and evaluate of Amoxicillin and potassium clavulanate dispersible tablet. The oral route is the most frequently used route for drug administration. Oral dosage forms are usually for systemic effects resulting from drug absorption through the various mucosa of the gastrointestinal tract. The parenteral route of administration is an important in mandatory condition; otherwise it is probable that at least 90% of all drugs used to produce systemic effects are administered by the oral route. The amoxicillin and potassium clavulanate dispersible tablets have been developed with direct compression method. The sixteen various compositions of formulations were prepared using Maize Starch, Sodium Starch Glycolate, Crospovidone, Croscarmellose sodium as a disintegrants. The powder blend were subject to various physical characteristics tests such as bulk density, tapped density, Hausner’s ratio, compressibility index and core tablets were evaluated for weight variation, hardness, thickness, disintegration time and the results were found within specification. In-vitro dissolution profile of sixteen formulations was carried out by using four disintegrants like Maize Starch, Sodium starch Glycolate, Crospovidone and Croscarmellose sodium. The In-vitro dissolution profile of F8 using croscarmellose sodium (15%) was found maximum release when compared to other formulations. The optimized batch tablets were packed in ALU-ALU pack and performed stability studies at 40°C/75% RH. All the results were found to be satisfactory. Sweetening agent i.e Aspartame and flavouring agent i.e strawberry flavour were used to increase palatability of the dispersible tablet. Hence the designed and developed formula of combination of Amoxicillin and Potassium Clavulanate dispersible tablets could be used as alternate dosage form.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Amoxicillin; Potassium Clavulanate Dispersible Tablet |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 09 Oct 2017 06:02 |
| Last Modified: | 09 Oct 2017 06:02 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3639 |
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