Ganesaramamoorthi, S (2013) Design and Evaluation of Gastroretentive Tablets of Levetiracetam. Masters thesis, Arulmigu Kalasalingam College of Pharmacy, Krishnankovil.
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Abstract
To prepare and evaluate Levetiracetam floating tablets based on gas forming agent. Levetiracetam is a broad-spectrum antiepileptic drug used in the treatment of partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures. Levetiracetam though rapidly and completely absorbed in the stomach and the small intestine, is comparatively less bioavailable in the lower part of the intestine. Levetiracetam is used as a monotherapy for seizures. Levetiracetam may be used as an alternative for the syndrome of juvenile absence epilepsy.Treatment of patients with seizures or epilepsy is often challenging. A person suffering from seizures has to strictly adhere to the medications every day. Even missing a dose of the drug may lead to fatality of the patients. The nootropic drug levetiracetam, has a half life of 6-8 hrs, suffers the disadvantage of multiple dosing in a day. To eradicate the disadvantage, the study was designed to reduce the dosage by designing it into a floatable drug delivery which will serve both the purpose of enhancing the absorption in the upper part of the GIT and further sustaining the release of the drug. The objective of present study was to develop floating tablets of levetiracetam in order to achieve an extended retention in the stomach and thereby increase the bioavailability and study the release characteristics with twelve formulations. The formulation was done by wet granulation method and the granules prepared were evaluated for the preformulation parameters such as bulk density, tapped density, angle of repose, carr’s index and hausner ratio. Tablets were prepared by wet granulation method. Tablets were evaluated for their physiochemical properties like angle of repose, hardness, friability, weight variation, thickness, compressibility studies, etc. Tablets were then subjected to in-vitro release in pH 1.2 gastric stimulating the pH of stomach for about 12 hours using dissolution apparatus.The dissolution profiles for the formulation showed an initial burst release followed by controlled and sustained release.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Gastroretentive Tablets; Levetiracetam |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 09 Oct 2017 06:00 |
| Last Modified: | 09 Oct 2017 06:00 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3637 |
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