Kartheeswaran, M (2013) Formulation Development and Evaluation of Ketoprofen Buccal Tablets. Masters thesis, C.L. Baid Metha College of Pharmacy, Chennai.
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Abstract
The present investigation was to formulate Ketoprofen buccal tablets containing 12.5mg, with a thickness of about 2mm and a diameter less than 4mm. Ketoprofen is a Non- Steroidal Anti-Inflammatory Drug, prescribed for the treatment of rheumatoid arthritis, osteo-arthritis and dental pain & inflammation. In general, Ketoprofen falls under BCS – class II (low solubility / high permeability), but pH dependent solubility behavior of Ketoprofen is used as the concept of designing buccal dosage form in present investigation, since the dose number of Ketoprofen is 0.00529. Therefore the objective of the formulation includes: Preparation of various formulations of Ketoprofen buccal tablets, using various grade of HPMC (K4M, K100 and E50) and different granulation technique for the manufacturing process, based on a 24-full Factorial design was the primary objective. Determination of the in vitro drug release profile and swelling index of the Ketoprofen buccal tablets was also included in the study. The buccoadhesive property and the ex vivo drug permeation for the various formulations are to be evaluated. Compiling the data in an optimization-software and analyzing the effect of different independent variables on the various responses is also the part of the investigation. The performance of evaluations, on the finished product dosage form of Ketoprofen buccal tablets, like weight variation, friability, hardness, and thickness, are to be included in the study. In order to determine the drug release kinetics, the ex vivo drug release data is to be fitted into the various kinetic models.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Ketoprofen Buccal Tablets; Optimization-software |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 11 Oct 2017 05:44 |
| Last Modified: | 11 Oct 2017 05:44 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3629 |
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