Umamaheswari, A (2012) Formulation and Evaluation of Controlled Porosity Osmotic Tablets of Lornoxicam. Masters thesis, College of Pharmacy, Madras Medical College, Chennai.
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Abstract
The Present study Lornoxicam (LOX) is a mainstay Non Steroidal Anti Inflammatory Drug (NSAID) for the treatment of inflammatory diseases like Rheumatoid Arthritis (RA) and Osteoarthritis (OA). But this drug has shorter half life (3-4 hours) and induces side effects when used for long term. The aim of the present study is To formulate controlled porosity osmotic tablets of LOX using mannitol as osmogen. To increase the solubility of LOX using tromethamine as solubility modifier and SLS as wicking agent. To release LOX in a controlled manner osmotically with cellulose acetate coating along with sorbitol as a pore former. The main objective of the study is to produce controlled release of LOX for the pain management of RA and OA and to improve the efficacy and patient compliance.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Osmotic Tablets; Lornoxicam |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 11 Oct 2017 05:36 |
| Last Modified: | 11 Oct 2017 05:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3626 |
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