Saravanan, K (2012) Formulation and Evaluation of Tablet in Capsule Device a Novel Approach for the Management of Pain with GI Protection. Masters thesis, College of Pharmacy, Madras Medical College, Chennai.
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Abstract
The Present study a Tablet in Capsule device containing Aceclofenac ER tablet and Misoprostol IR tablet for Pain Management with Gastro protection was formulated. Rationale of combining a NSAID and a prostaglandin analogue was well justified and the design of drug delivery system was made simple by encapsulating two different tablets (Aceclofenac and Misoprostol) in single capsule and it offers advantage in terms of GI protection, Patient Compliance and Chronotherapeutics. • Aceclofenac extended release tablet 200mg was formulated using various grades of hydrophilic polymer such as HPMC E50, HPMC K100 LV CR, HPMC K4M CR and HPMC K15M CR as release retardant to prolong the release for 12 hr . Misoprostol Immediate release tablet 200mcg was formulated using Crospovidone as superdisintegrant at 2%, 3% and 4%. Formulation characteristics such as precompression and postcompression studies of the developed formulations were carried out separately as per standard procedures. The tablets were found to be within the limits with respect to uniformity of weight, hardness, thickness, diameter, friability and drug content. In vitro dissolution studies for both the tablets were conducted separately. Aceclofenac ER formulation A8 was optimized based on the ideal release upto 12 hr The optimized Aceclofenac formulation followed Zero order release kinetics Based on the disintegration time Misoprostol IR formulation M3 was optimized The optimized formulations of Aceclofenac A8 and Misoprostol M3 were used for filling in size 0 elongated capsules. The stability studies under accelerated conditions of 40± 2°C /75±5% RH was found to be satisfactory.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Aceclofenac ER tablet; Misoprostol Immediate release tablet 200mcg; Crospovidone |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 11 Oct 2017 05:30 |
| Last Modified: | 11 Oct 2017 05:30 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3624 |
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