Formulation and Evaluation of Bilayer Tablets of Losartan Potassium for Immediate Release and Metformin Hydrochloride for Sustained Release

Nithin Kumar, P (2012) Formulation and Evaluation of Bilayer Tablets of Losartan Potassium for Immediate Release and Metformin Hydrochloride for Sustained Release. Masters thesis, College of Pharmacy, Madras Medical College, Chennai.

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Abstract

The present study was aimed to develop bilayer tablets of Losartan potassium as IR layer and Metformin hydrochloride as SR layer to treat hypertension in type II diabetic patients. Hypertension is also one of the complications of type II Diabetes. The bilayer tablets were formulated to reduce the polytherapy to monotherapy, thus improving patient compliance. The tablets were formulated using hydrophilic polymers such as HPMC K4M and HPMC K100M in varying ratios to retard the drug release for a period of 10 hours. The immediate release layer of Losartan Potassium was formulated using Sodium Starch Glycolate (2% and 4%). All the formulations were evaluated for physical characteristics, drug content, dissolution, release kinetics and stability studies. The main objective of the present study is to develop bilayer tablets containing Losartan potassium for immediate release and Metformin hydrochloride for sustained release for diabetic patients having hypertension. To provide effective, safe and stable pharmaceutical oral formulation containing an Antihypertensive drug Losartan potassium as immediate release layer and oral hypoglycemic drug Metformin hydrochloride as sustained release layer for effective treatment of hypertension in patients having Type-II diabetes mellitus.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Bilayer Tablets; Losartan Potassium; Metformin Hydrochloride
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 11 Oct 2017 05:28
Last Modified: 11 Oct 2017 05:28
URI: http://repository-tnmgrmu.ac.in/id/eprint/3622

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