Incidence of Papillary Neoplasms of Nervous System In a Tertiary Care Hospital. Role of Immunohistochemistry in Their Differential Diagnosis and Classification

Yogambal, M (2013) Incidence of Papillary Neoplasms of Nervous System In a Tertiary Care Hospital. Role of Immunohistochemistry in Their Differential Diagnosis and Classification. Masters thesis, Madras Medical College, Chennai.


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Nervous System Neoplasms Are Common Neoplasm Affecting Both Adults And Children. The Effects Of These Tumours Were Devastating Even Though They Constitute A Small Percentage Of All Cancers(1) Incidence, Prevalence And Survival Rates Are Important To Know The Burden Of Disease Among Different Populations. Over All Incidence Varies Between 9.21 To 18.1 Per 100,000 Person Years In Various Studies.(2,6,7) Variation In These Rates Prompted Us To Find Out Aetiology, Treatment And Prognosis Of The Disease (2). As Most Of The Studies Done On Nervous System Tumours Were Institutional They Were Prone For Bias Due To Inclusion And Exclusion Of Cases. In Developed Countries Like United States, Central Brain Tumour Registry Of United States (CBTRUS) Maintains The Brain Tumour Data From Various Cancer Registries. But In Developing Countries Like India, Due To Complete Lack Of Registration Of Newly Diagnosed Cases, With Local Registry The Exact Burden Of These Tumours Goes Unnoticed And Is Under Estimated. In These Settings Multi Institutional Tertiary Care Hospital Data Forms The Basis For Estimating The Disease Load. There Is Dire Need For Descriptive Data On Primary Brain And Nervous System Tumours As Highlighted By Kurland And Schoenberg(3). Hence This Study Is Contemplated With A View To Get Descriptive Data. In Contrast To Western Literature There Is No Report Exclusively Available For Brain Tumours In India. Among Tumours Of The Nervous System, Those With Papillary Configuration Constitute The Vast Majority And Produces Difficulty In Diagnosis. Papillary Neoplasms Of Nervous System Include Both Primary Central Nervous System And Spinal Cord Tumours As Well As Metastatic Papillary Tumours. Often The Histological Appearance Alone Cannot Conclude The Diagnosis. In Difficult Cases Use Of Immunohistochemistry Aid In Differentiating Metastasis From Primary Tumour, Histological Sub Typing And Grading. These Are Needed For The Proper Treatment And Prognostic Assessment. In This Study We Analysed The Data From Our Tertiary Care Hospital To Find The Epidemiology Of Papillary Neoplasms Of Nervous System, Histopathology, And Employed Immunohistochemistry To Differentiate Each Tumour.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Incidence Papillary Neoplasms ; Nervous System Tertiary Care Hospital; Immunohistochemistry ; Their Differential Diagnosis Classification;
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 23 Jun 2017 11:29
Last Modified: 23 Jun 2017 11:29

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