Chronological Effect on Insulin and Glycemic Status in Cancer Pain Patients

Neenu, B Niravath (2012) Chronological Effect on Insulin and Glycemic Status in Cancer Pain Patients. Masters thesis, Swamy Vivekanandha College of Pharmacy, Tiruchengode.


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Pain is the first sign of malignancy and prevalent symptom experienced by cancer patients. Circadian rhythm is the best known and probably most general rhythm in living creatures. It plays a very important role in the pattern of pain produced by various diseases. Time dependent variation affects perception of pain, its neurochemistry, and drug treatment. Endogenous insulin plays a critical role in the modulation of pain has been documented in clinical and preclinical studies. The aim of this study was to determine the insulin’s antinociceptive effect and also to study the influence of circadian rhythm on cancer pain. This study was done in Erode Cancer centre, Erode wherein we recruited 22 patients for the study. Patients were categorized as Group A, Group B, Group C. Group A included patients taking opiod drugs, Group B-patient taking nonopiods and Group C control patients without pain. Pain was assessed in patients using Visual Analogue Scale. Blood samples were collected from patients four times a day (6AM, 12PM, 6PM, 12AM)with their consent. Serum Insulin level were determined by ELISA method using DRG INSULIN KIT. Results were analyzed using computerized statistical package of Graphpad Instat Software. The statistical significance was tested by the analysis of variance(ANOVA) and Tukey - Kramer Multiple Comparisons Test. In opioid taking patients serum insulin level showed a increase in morning 6AM(31.3125±20.812 ) and afternoon 12PM (33.05±12.757). Whereas in nonopioid taking group increase in insulin level was found at evening 6PM (69.1875±21.290) and midnight 12AM(67.337±30.728). The serum insulin level in opioid and nonopioiod taking patients was increased and found highly significant(p value<0.0001) than control group although no significant differences in mean values of blood glucose were observed . In this study it was found that endogenous insulin play an important role in the modulation of pain in cancer pain and also circadian rhythm influences cancer pain

Item Type: Thesis (Masters)
Uncontrolled Keywords: Chronological Effect; Insulin; Glycemic Status; Cancer Pain Patients
Subjects: PHARMACY > Pharmacy Practice
Depositing User: Ravindran C
Date Deposited: 05 Oct 2017 05:15
Last Modified: 05 Oct 2017 05:15

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