Vijayalakshmi, M (2008) Pharmacognostic Phytochemical and Invitro Antilice and Antidandruff Activities of ichrostachys Cinerea (L.) Wight & Arn. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
This study covers the Pharmacognostic parameters of the leaves of Dichrostachys cinerea belonging to the Family Mimosaceae such as macroscopical, microscopical including powder analysis and physical standards like ash value extractive values etc have been studied and presented. The tissue arrangement in the leaf was studied and presented. The characteristic terminal sclereids were observed in the vein terminations. The presence of sclerenchymatous cells of gelatinous inner wall and outer lignified and dark solid bodies in pith cells were noted in the stem , so that the presence of stem powder in the leaf powder may be identified. The presence of tanniniferous material was noted in the mesophyll. The sensitive movement of leaves which is present is certain member of this family have been observed and presented. The preliminary phytochemical studies revealed the presence of carbohydrate, phytosterol, saponin, glycoside, tannin, protein and aminao acids, terpenoids. HPTLC profile was studied and presented. Bioactive fraction were isolated and one of the fraction contains β amyrin glycoside which was confirmed by IR, NMR & mass studies. The anti lice activity against Pediculus humanus capitis (head lice) after 90 minutes, of the ethanolic extract of leaves of D.cinerea in the concentration of 6gm/10ml was studied. The mortality is concentration dependent. It was further observed that the time for mortality from 90 minutes is reduced to 60 minutes when the extract was mixed with coconut oil as carrier oil. Application of aqueous paste not possess significant antilice activity. Isolated fractions were tested showed that the activity may be synergistic by the presence of various Phytoconstituents. We were also able to demonstrate invitro moderate anti dandruff activity of the ethanolic extract leaves of D.cinerea against M.furfur. The present study provide scientific basis for the ethnomedical use of this plant as antilice application. It is concluded that it can be optimistic that the present work proved D.cinerea of dual therapeutic advantage to be a potential phytochemical target in the design of a single drug for the treatment of both lice and dandruff without causing any adverse influences on eyes, to alleviate the suffering the affected individuals.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Pharmacognostic; Phytochemical; Invitro Antilice; Antidandruff Activities; ichrostachys Cinerea (L.) Wight & Arn |
| Subjects: | PHARMACY > Pharmacognosy |
| Depositing User: | Ravindran C |
| Date Deposited: | 05 Oct 2017 05:28 |
| Last Modified: | 06 Oct 2017 03:32 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3564 |
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