Gopalakrishnan, S (2008) Pharmacognostic Phytochemical and Invitro Platelet Aggregation Inhibitory Activity of Psidium Guajava Linn. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
This study covers the pharmacognostic parameters of the leaves of Psidium guajava Linn. Family : Myrtaceae such as macroscopical, microscopical, powder analysis, quantitative microscopy and physical standards like ash values, extractive values, which have been studied and presented. 9 varieties of P. guajava leaves namely Anakapalli, Bangalore, Chittidhar, Hafsi, Lucknow – 46, Lucknow – 49, Nagpur Seedless, Red fleshed, Smooth green were compared macroscopically and microscopically, to establish the botanical identity including anatomical variations. Specific anatomical characters pertaining to the leaf varieties were presented no difference in quantitative microscopy and other physical parameters like ash values, extractive values were found. The preliminary phytochemical studies of high yielding variety (Lucknow-49) leaves reveals the presence of carbohydrate, glycosides, proteins, sterols, saponins, tannin, flavonoid, terpenoid, volatile oil both in powder as well as extracts of various solvents. The isolated volatile oil from leaves of P. guajava shows presence of 37 components. Caryophyllene, aromadendrene were major constituents. New components in V.O ledol, 3 carene, muurolol were reported and absence of cineole, nerolidol, limonene which were reported earlier were found. The quercetin content of ethanolic extract of high yielding variety P.guajava (Lucknow – 49) leaves was determined by HPLC (1.2%w/w). A simple rapid, economical, reliable, laboratory scale micro slide method for the determination of preliminary platelet aggregation inhibitory activity was standardised and presented. Invitro Platelet aggregation inhibitory activity : The ethanolic extract of leaves of high yielding variety of P.guajava (Lucknow – 49) showed significant concentration dependent platelet aggregation inhibitory activity induced by agonists collagen and ADP. It may be due to the presence of quercetin. But the volatile oil showed no inhibitory activity.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Pharmacognostic; Phytochemical; Invitro Platelet; Psidium Guajava Linn |
| Subjects: | PHARMACY > Pharmacognosy |
| Depositing User: | Ravindran C |
| Date Deposited: | 05 Oct 2017 05:25 |
| Last Modified: | 06 Oct 2017 03:29 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3560 |
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