Use of antimicrobial coated polyglactin sutures versus plain polyglactin sutures in oral malignancies

Abhilasha Gloria, Singh (2016) Use of antimicrobial coated polyglactin sutures versus plain polyglactin sutures in oral malignancies. Masters thesis, Christian Medical College, Vellore.

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Abstract

OBJECTIVES: To study post operative wound infection rates in patients with oral malignancy following use of antimicrobial coated polyglactin 910 sutures as compared to plain polyglactin 910 sutures. METHODS: A pilot study of consecutive cases that underwent surgery for oral malignancies with all surgical sites being closed with triclosan coated polyglactin 910 sutures from 1st January 2014 to 31st July 2015. A total number of 53 patients were recruited and oral swabs was taken and sent for microbiological analysis prior to antibiotic administration. The overall wound infection rate was then compared retrospectively to the infection rate in the previous year in patients where the surgical sites sutured with plain polyglactin 910. Independent variables were analyzed by Chi-Squared test; multiple logistic regression was preformed to account for multiple risk factors. RESULTS & CONCLUSIONS: The overall wound infection rate in post operative patients who underwent oral malignancies surgery with triclosan coated polyglactin sutures was 17%. The wound infection rate had decreased from 23.86% when plain polyglactin sutures were used. Multivariate analysis was inconclusive and requires completion of the proposed sample size. The microbiological analysis revealed that the oral microbiology in patients with an oral malignancy is the same as those without. Nevertheless, this pilot study reveals that tumour staging of disease is a statistical significant factor to determine post operative surgical site infections.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Triclosan ; wound infection ; oral malignancy.
Subjects: MEDICAL > General Surgery
Depositing User: Subramani R
Date Deposited: 12 Oct 2017 01:01
Last Modified: 12 Oct 2017 01:01
URI: http://repository-tnmgrmu.ac.in/id/eprint/3548

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