Pratheep, J (2016) Clinical study of incidence of malignancy in solitary nodule of thyroid. Masters thesis, Tirunelveli Medical College, Tirunelveli.
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Abstract
BACKGROUND: Solitary nodule of thyroid has increased in incidence in the present day as compared to two decades before. Because of possibility of malignancy, some clinicians especially those in surgical subspecialities recommended that all nodules have to be removed. OBJECTIVES OF THE STUDY: 1. To determine the incidence of malignancy in solitary nodule of thyroid in general population and in relation to age and sex. 2. To determine the incidence of solitary nodule of thyroid turning out to be multi-nodular goiter. To study the incidences of euthyroid, hyperthyroid or hypothyroid states in patients presenting with solitary nodule of thyroid. 3. To study the role of FNAC in the management of solitary nodule of thyroid. 4. To determine the incidence of adenoma, carcinoma and thyroiditis as a cause of solitary nodule of thyroid in Tirunelveli Medical College, Tirunelveli. MATERIALS AND METHODS: Source of Data: Patients with Solitary nodule thyroid admitted to various surgical wards in Tirunelveli Medical College, Tirunelveli during the period of September 2014 - August 2015. Method of Collecting Data: Data collection by meticulous history taking and clinical examination, appropriate laboratory and radiological investigations, operative findings, histopathological report and follow up of cases. The study of minimum 50 cases selected by Random Sampling Technique admitted tc surgical wards of T.V.M.C, Thirunelveli during the period of September 2014 -August 2015. Inclusion Criteria: Patients admitted to surgical wards of T.V.M.C, Thirunelveli with features of SNT. Exclusion Criteria: •Patients with diffuse enlargement of thyroid. •Patients presenting with MNG clinically*. •Patients refusing for investigations / management. RESULTS: Commonest presentation of solitary thyroid nodule was asymptomatic. The Peak incidence of solitary nodule was observed in 3rd to 5th decade, constituting 60% of the cases studied. Females predominated in number over males in occurrence of solitary nodule in ratio of 1:11.5. 36% of all clinically solitary nodule turned out to be multi-nodular goiter. The common causes of solitary nodule was MNG (36%), follicular adenoma (22%), adenomatous goiter (24%). 94% 0f cases presented with euthyroid state. Incidence of malignancy in solitary thyroid nodule was 12%. Male to female ratio in case of malignant nodule was1:5. Incidence of carcinoma in males presenting as solitary nodule was higher (25%) compared to that of females (10.87%). The most common cause of malignancy was papillary carcinoma (67%) followed by follicular carcinoma (33%). . INTERPRETATION AND CONCLUSION: Solitary nodule of thyroid is more common in 3rd to 5th decades. Solitary nodule of thyroid are more common in females. Most of the patients presenting with solitary nodule of thyroid are euthyroid and only a small percentage of patient with toxicity or hypothyroidism USG can be accurately used to detect patients with multinodulary goiter who clinically present as solitary nodule of thyroid. Common causes of solitary nodule of thyroid are MNG, follicular adenoma and adenomatous goiter. Incidence of malignancy in male patients presenting with solitary nodule of thyroid is more when compared to female. The most common cause of malignancy in solitary nodule is papillary carcinoma followed by follicular carcinoma.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | solitary nodule ; malignancy ; euthyroid. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Oct 2017 01:00 |
| Last Modified: | 12 Oct 2017 01:00 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3547 |
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