Comparative analysis of biliary cholesterol levels in iron deficient and non-iron deficient patients operated for gall stone disease

Ajay Varun Reddy, T (2016) Comparative analysis of biliary cholesterol levels in iron deficient and non-iron deficient patients operated for gall stone disease. Masters thesis, Kilpauk Medical College, Chennai.


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BACKGROUND AND OBJECTIVE: Gall Stone disease is a common clinical entity affecting adult population of both sexes. The old saying, that gall stone sufferer is a fat, fertile, female of fifty is only partly true, as the disease has been observed in women after their first delivery and also in underweight and thin people. Several etiological factors have been studied in the formation of gall stones. There has been recent interest in establishing the role of several nutritional trace elements in the pathogenesis of gall stone disease. Iron Deficiency is a new and particularly interesting parameter which has been studied lately, but with a few studies showing conflicting results. Establishing the role of Serum Iron in the etiology of Gall stones is of special importance in our population group because of the huge prevalence of nutritional deficiencies. It also provides scope for early detection, treatment and risk modification if its role as an etiologic/risk factor is clearly defined. AIM: The study is aimed at establishing the role of iron deficiency in the super saturation of bile with respect to cholesterol, which leads to gall stone formation. METHODS: A study was done between December 2014 to September 2015 at the department of General Surgery.50 patients suffering from Cholelithiasis, confirmed by USG, were divided into two groups based on serum iron values. Group A, consists of patients with normal serum iron (non-anaemic) and group B, of patients with less than normal serum iron (anaemic). Serum Iron, Biliary Cholesterol and Serum Cholesterol of all the patients was obtained. The Biliary cholesterol levels and Serum cholesterol levels of both the groups was analysed by using a student t-test. RESULTS: Out of the 50 Patients, 40 (80%) were female and 10 (20%) were males. The female to male ratio was 4:1. The Biliary Cholesterol values for Group A and B respectively were 754.5 ± 398.3 and 1184.7 ± 405.2 mg/dl. The Biliary Cholesterol levels were significantly higher in the Iron Deficient group (Group B) than compared to the Non-Iron Deficient Group. This result was extremely statistically significant with a p value of <0.0004. Similarly, an independent t-test comparing Serum Cholesterol levels in Non-Iron Deficient (184.8 ± 35 mg/dl) and Iron Deficient subjects (171 ± 49.3 mg/dl) did not find a statistically significant difference. (p=0.2544). CONCLUSION: These results suggest that Iron Deficiency has an association with Biliary Cholesterol Levels.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Biliary Cholesterol ; Iron Deficiency ; Gall Stone Disease.
Subjects: MEDICAL > General Surgery
Depositing User: Subramani R
Date Deposited: 12 Oct 2017 00:46
Last Modified: 18 Oct 2017 05:15

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