Clinicopathological and Immunohistochemical Profile of Malignant Surface Epithelial Ovarian Tumors.

Kuzhalmozhi, M (2013) Clinicopathological and Immunohistochemical Profile of Malignant Surface Epithelial Ovarian Tumors. Masters thesis, Madras Medical College, Chennai.

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Abstract

Ovarian Tumors Are The Most Common Neoplasms In Women. Among The Various Gynecological Tumors, The Pathology Of Ovarian Neoplasms Is More Complex, Because The Ovary Gives Rise To Various Types Of Tumors Than Any Other Organ. The Origin Of Ovarian Tumour Is Often In Disparity1. Ovarian Tumours Accounts For Larger Proportion Of Clinically Important Problems And They Are Usually Dangerous Because Of Their Silent Growth. Worldwide, Ovarian Tumor Constitutes Sixth Most Common Tumor In Women. Ovarian Carcinoma Is The Fifth Most Common Malignancy In The Western Countries And Ranks Fourth In Cancer Mortality2. In India, Ovarian Cancer Is The Most Lethal Gynecologic Malignancy Which Ranks 2nd After Cervical Cancer. In Chennai, Ovarian Cancer Stands In The Third Position3. This High Mortality Is Because Of Difficulty In Diagnosing Ovarian Cancer At An Early Stage And Absence Of Effective Therapies For Advanced Stage Disease 4. PLCO Screening Programme Is The Ongoing Trail Designed For Effective Screening Of Ovarian Cancer Which Includes Transvaginal USG And CA 125 Level. The Aim Of This Programme Is To Diagnose Ovarian Tumors When They Are Still Confined To The Ovaries. By This The Mortality Of The Disease Is Reduced And Effective Cure Can Be Obtained5. Ovarian Carcinoma Exhibits A Wide Range Of Morphological Phenotypes. Since More Than 90% Of Ovarian Cancers Are Of Epithelial Cell Origin, Various Genetic Alterations Occur During Malignant Transformation Of Ovarian Epithelial Cells. Several Studies On The Molecular Pathways Of Carcinogenesis Provides Explanation For The Different Morphologic Phenotypes And The Prognostic Behavior Of Ovarian Carcinoma. Genomic Studies On Surface Epithelial Ovarian Tumors Have Proposed A New Method Of Classification Based On Their Gene Expression Patterns. Type I Tumors Are Genetically Stable And Are Characterized By Mutations In A Number Of Different Genes Including KRAS, BRAF, PTEN, And Beta-Catenin. Type II Tumors Show High Level Of Genetic Instability And Is Characterized By Mutation Of TP537 Women With A Family History Of Ovarian Carcinoma Or Who Have BRCA 1/2 Mutations Shows Reduced Risk For Tumor Development Following Prophylactic Hysterectomy And Bilateral Salpingo-Oophorectomy. Immunohistochemical Markers Like Cytokeratin Have Been Used In The Diagnosis Of Ovarian Tumors. Recently Various Studies On Prognostic Significance Of P53, Her-2neu, Overexpression In Epithelial Ovarian Cancer Suggests Poor Prognosis And Decreased Survival Benefit. More Than 30% Epithelial Ovarian Cancer Shows Amplification And Over- Expression Of ERBB2 Gene And They Are Associated With Worse Prognosis8. P53 Overexpression Shows An Aggressive Behavior And Is Associated With More Rapid Spread Of Disease. Hence IHC Is Used To Measure The Her 2 Neu And P53 Protein Overexpression Present In The Epithelial Tumors. This Study Is Undertaken In View Of Evaluating The Incidence, Age, Clinical Features, Histopathological And Immunohistochemical Features Of Epithelial Ovarian Tumors And Its Prognostic Significance. In Addition, The Recent Literatures, Journals And Research Publications On Ovarian Tumors Are Also Reviewed.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Clinicopathological; Immunohistochemical Profile; Malignant Surface Epithelial Ovarian Tumors
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 23 Jun 2017 11:47
Last Modified: 23 Jun 2017 11:47
URI: http://repository-tnmgrmu.ac.in/id/eprint/352

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