Novel Approaches on the Design and Evluation of Floating Drug Delivery Systems of Glipizide

Ramya Devi, D (2008) Novel Approaches on the Design and Evluation of Floating Drug Delivery Systems of Glipizide. Masters thesis, Madurai Medical College, Madurai.


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Diabetes mellitus is a progressive and complex disorder that is difficult to treat effectively in the long term. There is an extensive range of oral anti‐diabetic drugs, indicated for the treatment of type II (non‐insulin dependent) diabetes mellitus which may be used as mono therapy or in combination with others.Glipizide is a second generation sulphonyl urea used as an oral anti diabetic medication in the treatment of type 2 diabetes. It controls blood sugar level by stimulating the pancreas to secrete more insulin. Even though Glipizide is readily absorbed after oral administration, it is metabolized by hydroxylation to form a number of inactive metabolites and the plasma half life is only 2 to 4 hours. Its short biological half life necessitates that it be administered in 2 or 3 doses of 2.5 – 10 mg / day. Thus the development of sustained release dosage form would be clearly advantageous. the present study clearly indicate the feasibility to develop Glipizide in the form of Floating Drug Delivery System with prolongation of gastric retention time and sustained drug release. The future studies may be extended to reveal the pharmacokinetic parameters and clinical trial investigations, which may prove that the formulation can be administered safely for the treatment of Type II Diabetes with improved therapeutic efficacy.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Floating Drug Delivery Systems; Glipizide
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 03 Oct 2017 10:00
Last Modified: 03 Oct 2017 10:00

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