Mohanambal, E (2010) Formulation and Evaluation Of PH Triggered In Situ Gelling System of Levofloxacin. Masters thesis, Madurai Medical College, Madurai.
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Abstract
The present study is to formulate and evaluate the pH-triggered in situ gelling system to deliver sustained drug release.Due to the gelling capacity of the pH-triggered in situ gelling system after instillation in to the eye by increase in pH of tear fluid, the drainage of formulation is minimal compared to conventional ophthalmic eye drops. The in situ gelling system provides longer contact time and sustained delivery of the drug, hence decrease in frequency of administration and improved patient compliance are the major advantages. The ocular conjunctivitis caused by various micro organism causes permanent conjunctival damages, corneal ulceration, systemic infections. The role of topical quinolones reserved principally for severe bacterial conjunctivitis.22 The second generation flouroquinolone, levofloxacin 0.5% solution is 2 times potent than the ofloxacin ophthalmic solution and hence selected as a drug in the formulation of pH-triggered in situ gelling system. The formulation of pH-triggered in situ gelling system would be a alternative to conventional marketed eye drops by providing sustained drug release and improved patient compliance due to less frequency in administration.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | PH Triggered; Situ Gelling System; Levofloxacin |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 03 Oct 2017 09:59 |
| Last Modified: | 03 Oct 2017 09:59 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3446 |
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