Formulation and Evaluation of Topical Drug Delivery System Containing Clobetasol Propionate Niosomes

Abraham Lingan, M (2008) Formulation and Evaluation of Topical Drug Delivery System Containing Clobetasol Propionate Niosomes. Masters thesis, Madurai Medical College, Madurai.


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Glucocorticosteroids are used topically for a large variety of dermatological conditions. They benefit by virtue of their anti inflammatory, immune suppressive, vasoconstrictor and antiproliferative actions31,68. However, even though glucocorticoids can be used to treat vast skin disorders it also have some side effects. Moreover the premature withdrawal of corticosteroids will result in relapse of the disease. So less frequent application of a superpotent corticosteroid in a suitable carrier may have prolonged action with less or minimal side effects69. To achieve the above aim, niosome is one of the right choice. Since they can entrap both hydrophilic and lipophillic drugs, it can be employed as a suitable drug carrier for steroidal drugs.According to structure activity relationship of steroidal drugs addition of fluorine atom at position 6 and/or 9 enhance the potency of steroid. 17th hydroxy group is also important to glucocorticoid activity. So glucocorticosteroid Clobetasol propionate is choosen. Then various Clobetasol propionate niosomes were prepared by altering the ratios between various non ionic surfactants (span series) and cholesterol by three methods such as Thin film hydration method, Ether injection method and Hand shaking method. The prepared niosomes were subjected to drug content analysis, Entrapment efficiency and Invitro drug release studies. The best niosomal preparations were subjected to size analysis by scanning electron microscopy and it is formulated as gel. Finally the niosomal gel and marketed gel were subjected to invitro drug release studies and invivo animal studies. This study it is concluded that the niosomes can be considered as promising drug delivery vehicles which increase the duration of action of the drugs. Thus niosomes help in formulating dosage forms having more prolonged action. The niosomal delivery of clobetasol propionate in carbopol gel base acts as a suitable topical drug delivery system which may be given safely to all patients suffering from skin disorders (above 12yrs). The gel produces smoothness and cooling effect with more compatibility with the skin surface.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Topical Drug Delivery System; Containing Clobetasol Propionate Niosomes
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 03 Oct 2017 09:58
Last Modified: 03 Oct 2017 09:58

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