Praveen, C (2009) Formulation and Comparative Evaluation of Proniosome Hydrocortisone Gel with Marketed Formulation. Masters thesis, PSG College of Pharmacy, Coimbatore.
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Abstract
The present study is hydrocortisone gel was carried out using Himedia dialysis membranes 50 with the molecular weight cut-off range from 12000 - 14000. A weighed amount of (100 mg) Proniosomal gel formulation was dispersed in the dialysis membrane and the open ends of the membrane were covered with membrane closure clips. The membrane containing gel formulation was allowed to dip in 50 ml of receptor medium pH 7.4 phosphate buffer saline. The receptor medium was stirred using magnetic bead fitted to a magnetic stirrer at 60 rpm. Samples were withdrawn and replaced by equal volumes of fresh receptor medium at each sampling intervals to maintain sink condition. Samples withdrawn were analyzed by using spectrophotometer at 248 nm. The proniosome hydrocortisone gel 1% and 2.5% was prepared by using various surfactant combinations by coacervation phase separation method. The in vitro permeation of different formulations containing mixture of non-ionic surfactants have been studied and evaluated. The cumulative release from (S20: 80 1 %) PHG was 58.92 ± 0.627. Proniosome hydrocortisone gel shows diffusion release type which was confirmed by Higuchi and Peppas plot. Comparison of Proniosome formulation with marketed 1 % hydrocortisone cream, proniosome formulation shows better cumulative release and anti inflammatory activity than in marketed formulation. Phospholipids and non-ionic surfactants in an optimum ratio in the Proniosomes may act as penetration enhancers, which are useful for increasing the permeation of hydrocortisone through skin.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Comparative Evaluation; Proniosome Hydrocortisone Gel; Marketed Formulation |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 03 Oct 2017 09:56 |
| Last Modified: | 03 Oct 2017 09:56 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3437 |
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