Prasath, R (2009) Formulation and in Vitro Evaluation of Zidovudine Microspheres. Masters thesis, PSG College of Pharmacy, Coimbatore.
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Abstract
The present study was to formulate and evaluate microencapsulated controlled release preparations of Zidovudine using ethyl cellulose as the retardant material with high entrapment efficiency and extended release. Ethylcellulose is a natural, biodegradable polymer and the method adopted for preparing microsphere was water-in-oil-in-oil (w/o/o) double emulsion solvent diffusion technique. Novel drug delivery system is finding more attention in pharmaceutical industries due to its various advantages. In the line sustained/controlled release formulations are more focused for improving the drug bioavailability with less dosing frequency. Zidovudine is one such compound having a poor bioavailability with high dosing frequency. The present investigation is focused to develop a suitable sustained release formulation for achieving better bioavailability and reduce dosing frequency. Zidovudine was formulated as microspheres using ethylcellulose. Compatibility studies were carried out using FTIR. The results suggest no evidence of any interaction. Different batches containing various concentrations of drug, polymer with varying volume of dispersion medium was prepared by double emulsion solvent diffusion technique. The in vitro release suggest that low volume of dispersion medium and low polymer ratio 64.05% of release at the end of 24 hrs with 65.12 % entrapment. It is evident that zidovudine loaded ethylcellulose microspheres showed better sustained release profile which is up to 24 hrs. The prepared formulation can be further evaluated to achieve a better bioavailability. IN VIVO studies can be carried out to optimize the Zidovudine microspheres using ethyl cellulose. The pharmacokinetic behavior of the formulated microspheres can be studies for optimization of the formulation.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Vitro Evaluation; Zidovudine Microspheres |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 03 Oct 2017 04:58 |
| Last Modified: | 03 Oct 2017 04:58 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3435 |
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