Muthukumar, - (2009) HSV2 Inhibition With HIV Suppressing Nanoparticles for Targeted Drug Delivery of Macrophages/Monocytes. Masters thesis, PSG College of Pharmacy, Coimbatore.
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Abstract
Herpes simplex virus (HSV) is a human DNA virus with two species, HSV-1 and HSV2, that causes a variety of disease manifestations. The major public health importance of HSV2 lies in its potential role as a cofactor for HIV transmission. Valacyclovir is an oral antiviral drug which included in the antiretroviral therapy prolongs survival in HIV seropositive individuals. The Valacyclovir is having low bioavailability profile with toxicity and adverse reactions in high dose. The present work was proposed to prepare MMA-SPM nanoparticles loaded with Valacyclovir to achieve better bioavailability with lowest possible dose. From the plethora of literatures it was found that MMA-SPM NPs are suitable carrier for hydrophilic or even charged molecules (Langer et al., 1997). The MMA-SPM nanoparticles were prepared and the drug was loaded in different pH environment. The prepared NPs are evaluated for different parameter. The particle size and surface morphology results revealed that the nanoparticles are in the size range of 80 – 110 nm. Which may be useful for targeting the Nps to macrophages or monocytes. The in vitro release suggests that the Nanoparticles shows a better controlled release profile for more than 24 hrs. The frequency of the doses can be reduced due to the controlled release nature. The NPs is targeted delivery devices which will be useful to reduce the dose level of Valacylclovir. To conclude, the prepared nanoparticles may be used to achieve the better bioavailability profile with targeting to the macrophages. The in vivo studies may be carried out to optimize the therapeutic response of the prepared nanoparticles.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | HSV2 Inhibition; HIV Suppressing Nanoparticles; Targeted Drug Delivery;Macrophages; Monocytes |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 03 Oct 2017 04:59 |
| Last Modified: | 03 Oct 2017 04:59 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3432 |
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