John, R (2009) Targeted Drug Delivery of Capecitabine Microspheres for Colorectal Cancer. Masters thesis, PSG College of Pharmacy, Coimbatore.
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Abstract
Colorectal carcinoma is the second leading cancer killer and third most common cancer throughout the world. Capecitabine is a new drug for orally administered and widely used for the treatment of colorectal cancer. The first pass metabolism of capecitabine is a problem in achieving bioavailibility. Development of colon targeting microspheres will be the promising technique to avoid first pass metabolism and to achieve the desired bioavailibility profile. The present study is focused on development of capecitabine loaded alginate microspheres and filled in capsules followed by Eudragit-S-100 coating for targeting to colon region. The results suggested that drug, 4% sodium alginate 1:2 ratio with 2% cross linking agent (FA2) was found to be the best formulation and showed 87.1% release in 2hrs with 79.7% entrapment. So the formulation is selected for further coating with Eudragit-S-100 for targeting to colon region. The coated capsules release studies shows no evidence of drug release for up to 6hrs. It is evident that the GI emptying time can be bypassed by the coated capsules the drug release of 51% at the end of 10hrs from coated capsules. Suggests the Eudragit-S-100 coating only degrading in colon pH. The prepared formulation can be further evaluated in vivo for correlating in vitro study results. The prepared microspheres is a promising colon targeted delivery device for achieving better kinetic profile with improved bioavailibility.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Targeted Drug Delivery; Capecitabine Microspheres; Colorectal Cancer |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 03 Oct 2017 04:56 |
| Last Modified: | 03 Oct 2017 04:56 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3431 |
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