Sreejith, G (2012) Formulation Development and Evaluation of Taste Masked Cefuroxime Axetil Oral Suspension. Masters thesis, KMCH College of Pharmacy, Coimbatore.
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Abstract
This study is formulation development and evaluation of taste masked Cefuroxime Axetil Oral suspension. Many conventional tablets are available in adult strength and the administration of accurate dosage for children is critical. Oral suspension can be formulated in paediatric strength. Swallowing difficulty is another drawback with conventional tablet dosage form, that can be overcome by Oral suspension formulation. Cefuroxime Axetil is a second generation cephalosporin antibiotic. It is used in the treatment of uncomplicated urinary tract infections, respiratory tract infections, otitis media, and Lyme disease. The taste of Cefuroxime Axetil is extremely bitter. Marketed preparations of Cefuroxime Axetil currently available are not completely devoid of bitterness problem. So children cannot tolerate the bitter taste of the drug and vomit out during administration. The formulation of taste masked oral suspension was aimed to administer Cefuroxime Axetil in a more palatable form to obtain a “patient-friendly dosage form” especially for paediatric patients and hence that will increase the patient compliance. In the present work the problem is addressed and better taste masking methodologies were used for rectification. The bitter taste still persist even after increasing the amount of sweetener and flavour; the average dissolution value falls far less than the expected limit of 60 %. Hence it was concluded that taste masking of Cefuroxime axetil oral suspension with sweetener and flavour technology was unsatisfactory. Therefore, alternate method was adopted in the next trial.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Cefuroxime Axetil Oral Suspension; Cefuroxime Axetil; Generation cephalosporin antibiotic |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 03 Oct 2017 04:54 |
| Last Modified: | 03 Oct 2017 04:54 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3426 |
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