Sravan Kumar, Aligeti (2009) Formulation, Development and Evaluation of Ketorolac Tromethamine Film Coated Tablets. Masters thesis, Padmavathi College of Pharmacy, Dharmapuri.
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Abstract
The Study was formulate, develop and evaluate ketorolac romethamine different excipients. Preformualtion study was done initially and results directed for the further course of formulation. Based on preformulaion studies different batches of ketorolac were prepared using selected excipients. Blend evaluated for tests loss on drying, bulk density, tapped density, compressibility index, Hausner ratio before ring punched as tablet. Tablets were tested for weight variation, thickness, hardness, friability and in vitro drug release as per official procedure. Change in dissolution parameter study made it suitable for minute physiological variables. From the above results and discussion it is concluded that formulation ketorolac tromethamine containing 50% of micro crystalline cellulose, disintegrating agent Colloid silicon dioxide in Batch-VIII can be taken as an ideal or optimized formulation, it fulfills the requirements for short term release tablet and our study encourages for the further clinical trials and long term stability study on this formulation.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Ketorolac Tromethamine Film Coated Tablets; Crystalline cellulose |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 27 Sep 2017 11:35 |
| Last Modified: | 27 Sep 2017 11:35 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3414 |
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