Navya, A (2012) Formulation and Evaluation of Gastroretentive Floating Microspheres of Esomeprazole Magnesium Trihydrate. Masters thesis, Padmavathi College of Pharmacy and Research institute, Dharmapuri.
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Abstract
The present study, microspheres are prepared using Emulsion-Polymerization method. In this method, polymeric drug solution i.e., drug + polymer and solvent system (DicloroMethane + Ethanol) of 10 ml is added to 10 % solution of egg albumin. This polymeric phase is stirred continuously to form a uniform dispersion. In another beaker 86 ml of coconut oil containing 1 ml of 0.5% Sodium Lauryl Sulphate is taken which forms the organic phase. The polymeric phase is added drop wise using needle into the organic phase. It is continuously stirred for 2 hrs with a speed of 700 rpm using stirrer. After stirring 1 ml of formaldehyde is added and obtained microspheres are washed thrice with 20 ml of η–hexane and the obtained final microspheres are stored in a dessicator.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Gastroretentive; Floating Microspheres; Esomeprazole; Magnesium Trihydrate |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 27 Sep 2017 11:36 |
| Last Modified: | 27 Sep 2017 11:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3413 |
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