Effect of chlorhexidine scurb on surgical site infection: A hospital based randomised study

Kamalraj, S (2016) Effect of chlorhexidine scurb on surgical site infection: A hospital based randomised study. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.


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AIM: To study the effect of chlorhexidine scrub on surgical site infection, in comparison with povidone iodine. OBJECTIVES: To assess the effect of Chlorhexidine scrub on surgical site infection over Povidone-Iodine. (I) To assess the microbiological organisms found in surgical site infections. (II) To assess the other risk factors contributing to the surgical site infections. METHODOLOGY: 300 patients who underwent elective surgeries from the department of general surgery, cardiothoracic surgery and pediatric surgery were prospectively studied. Detailed clinical history, pre and post operative evaluation were done for all patients. Patients were screened for any evidence of surgical site infection. The microbiological profile was analyzed in detail for infected cases. Patients were subjected into two groups. One group of patients underwent betadine scrub and the other group underwent chlorhexidine scrub pre operatively and were then compared using univariate analysis. In order to identify the risk factor for the presence of surgical site infection, analysis by logistic regression were done. Each patient was followed for a period of 30 days to assess the status of wound healing and any evidence of surgical site infection. The impact of surgical site infection was assessed by analyzing the associations of duration of hospital stay, any post operative complications, status of wound at the end of 30 days with any evidence of surgical site infection using appropriate statistical tools. The influence of other factors on surgical site infection were analysed by the same statistical tools. RESULTS: Surgical site infections were isolated from 14 patients out of 300 (4.66%). 50% of isolated organisms (7 out of 14) were found in surgical site. The commonest organism isolated in one study was Escherichia coli followed by Klebsiella and Staphylococcus spp., by univariate analysis. Patient’s age, co morbid conditions, socio-economic status, length of hospital stay, ASA scoring, duration of surgery, skin closure type, obesity, were associated with significance in those with MDRO infected foot ulcers. Analysis by logistic regression indicated that about 3 factors significantly increased the risk of acquiring SSI infections. 1. Skin closure type= suture, staples 2. Duration of surgery 3. Length of post op stay CONCLUSION: Effect of chlorhexidine scrub showed significant reduction in surgical site infection. Usage of chlorhexidine scrub as pre-operative skin preparation had significant reduction in surgical site infection when compared to the use of povidone iodine. Factors like type of cases (clean/clean contaminated), duration of surgery, length of hospital stay had significant impact in the development of surgical site infections.

Item Type: Thesis (Masters)
Uncontrolled Keywords: chlorhexidine scurb ; surgical site infection ; hospital based randomised study.
Subjects: MEDICAL > General Surgery
Depositing User: Subramani R
Date Deposited: 27 Sep 2017 03:31
Last Modified: 27 Sep 2017 03:31
URI: http://repository-tnmgrmu.ac.in/id/eprint/3390

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