A study on the effect of carbondioxide as pneumoperitoneum on liver functions in laproscopic cholecystectomy

Chandrasekaran, K (2016) A study on the effect of carbondioxide as pneumoperitoneum on liver functions in laproscopic cholecystectomy. Masters thesis, Stanley Medical College, Chennai.


Download (593kB) | Preview


AIM OF THE STUDY: 1. To study the incidence of alterations in liver function following laparoscopic cholecystectomy in the Indian population 2. To study the significance of these alterations in patients and the safety of the procedure MATERIALS AND METHODS: This is a prospective study conducted in the department of General surgery, Stanley medical college, Chennai, from July 2014 to June 2015. This chapter presents an overview of the study design of LC performed under variable intraperitoneal pressure (12-14mmHg) in patients with cholecystectomy. SOURCE OF DATA: The patients admitted in our hospital wards with symptomatic cholelithiasis from July 2014 to June 2015 will be taken up for the study. METHOD OF COLLECTION OF DATA: The study will be conducted on 50 patients undergoing LC under variable intraperitoneal pressure (12-14mmHg) at Stanley medical college, chennai. The study will be designed to evaluate the complications of LC especially the changes in liver enzymes. All patients undergoing laparoscopic cholecystectomy will be invited to participate in the study and written informed consent will be taken. All patients will undergo a standard clinical and laboratory evaluation that includes briefly information about age, sex, address and routine investigation including ultra sound abdomen, which are done pre operatively. Pre-operative investigations include liver function tests (SGOT, SGPT, alkaline phosphatase, gamma glutamyl transferase, bilirubin (direct), and bilirubin(total)). The subject satisfying inclusion and exclusion criteria will be enrolled in the study. The liver function tests will be further done 24 hrs later and in some patients liver function test will be repeated to monitor liver function. Adverse events will be noted in all the patients. Finally the duration of hospital stay will be noted. The patients who develops intraabdominal complications will be excluded from the study. CONCLUSION: This prospective observational type of study was conducted in department of General Surgery, Stanley Medical College and Hospital, Chennai, from 1 July 2014 to 30 June 2015. It can be concluded from the findings of the study that usage of co2 as pneumoperitoneum in laproscopic cholecystectomy has no significant effect on post operative liver enzymes. It can be concluded that variation in insuffulation pressure has no effect on enzyme rise significantly. It can be observed that duration of surgery with co2 pneumoperitoneum has no effect on postoperative LFT level. Thus co2 in safe pneumoperitoneum can be safely used in laproscopic surgeries.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Laproscopic cholecystectomy ; Co2 pneumoperitoneum ; liver function test.
Subjects: MEDICAL > General Surgery
Depositing User: Subramani R
Date Deposited: 27 Sep 2017 02:13
Last Modified: 27 Sep 2017 02:13
URI: http://repository-tnmgrmu.ac.in/id/eprint/3378

Actions (login required)

View Item View Item