Treatment of lateral epicondylitis with platelet rich plasma or corticosteroid injection: A Short term Comparative study

Ramanan, N S (2014) Treatment of lateral epicondylitis with platelet rich plasma or corticosteroid injection: A Short term Comparative study. Masters thesis, Coimbatore Medical College, Coimbatore.

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Abstract

BACKGROUND: Lateral epicondylitis is the commonest chronic disabling painful condition of the elbow. Elbow pain and tenderness with resisted wrist extension are common manifestations in lateral epicondylitis. Recent studies have suggested platelet rich plasma (PRP) to be a safe and effective therapy for tennis elbow. PURPOSE: To compare the effectiveness of single dose injection of autologus platelet rich plasma with corticosteroid injection in treatment of lateral epicondylitis and to measure the outcome in a short term follow up study. STUDY DESIGN: Randomized controlled trial METHODS: A total of 40 patients with lateral epicondylitis were treated at Coimbatore Medical Hospital, April 2014 to June 2014 over 3 months. All patients had minimum three months of symptoms. Randomization and allocation to the trial group were carried out by a lot method. The platelet rich plasma (PRP) was prepared from venous whole blood. After receiving a local anesthetic, all patients had single dose injection of autologus platelet rich plasma with corticosteroid injection in their extensor tendons at elbow. Patients received either an autologous platelet rich plasma injection or a corticosteroid injection through a peppering needling technique. The primary analysis included visual analog scale (VAS) pain scores and Disabilities of the Arm, Shoulder and Hand (DASH) outcome scores RESULTS: The PRP group was more often successfully treated than the corticosteroid group. When baseline VAS and DASH scores were compared with the scores at 12 weeks follow up, both groups showed improvement across time (intention-to-treat principle). However, the VAS and DASH scores of the corticosteroid group have not shown improvement, while those of the PRP group showed improvement at the end of 12 weeks (as treated principle). There were no complications related to the use of PRP. CONCLUSION: Treatment of patients with lateral epicondylitis with PRP reduces pain and increases function significantly, exceeding the effect of corticosteroid injection at the end of 12 weeks follow up. Future decisions for application of PRP for lateral epicondylitis should be confirmed by more number of patients and further follow up and should take into account possible costs and harms as well as benefits.

Item Type: Thesis (Masters)
Uncontrolled Keywords: lateral epicondylitis ; platelet ; platelet rich plasma (PRP); corticosteroid ; tennis elbow.
Subjects: MEDICAL > Orthopaedics
Depositing User: Subramani R
Date Deposited: 26 Sep 2017 00:58
Last Modified: 26 Sep 2017 00:58
URI: http://repository-tnmgrmu.ac.in/id/eprint/3331

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